TGF-β signaling in the aortic wall of Fbn1C1039G/+ mice. Losartan can improve disease manifestations in the lungs, an event that cannot plausibly relate to improved hemodynamics. Losartan (10 mg/kg, intraarterial injection) increases blood angiotensin levels four- to sixfold. Losartan (10 ...
Losartan (0.6 g/L, p.o.) -treatedFbn1C1039G/+mice show a reduction in distal airspace caliber relative to placebo-treatedFbn1C1039G/+animals. The doses of losartan and propranolol are titrated to achieve comparable hemodynamic effects. Analysis of pSmad2 nuclear staining reveals that losar...
Bar-Klein G, Cacheaux LP, Kamintsky L, Prager O, Weissberg I, Schoknecht K, Cheng P, Kim SY, Wood L, Heinemann U, Kaufer D, Friedman A (2014) Losartan prevents acquired epilepsy via TGF-beta signaling suppression. Ann Neurol 75(6):864-875....
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor-beta (TGF-beta) family of cytokines. We show that aortic aneur...
Soluble klotho acts an endocrine factor with diverse functions including endothelium protection and reducing inflammation and fibrosis through mechanisms involving Wnt and TGFbeta1 signaling. Renal fibrosis is the end stage of the progressive chronic kidney disease (CKD) and renal klotho is markedly ...
Losartan is an angiotensin II type 1-receptor blocker that has been shown to attenuate TGF-β signaling in some disease states. Aortic-root growth in mice with Marfan's syndrome treated with losartan is similar to wild-type mice. In the mouse model the beta-blocker propranolol also reduces ...
trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-beta in streptozotocin-induced diabetic rats Fibrosis is a pathological process in diabetic nephropathy that causes renal failure and dysfunction. Given the known anti-diabetic effects of trans-Anetho...
[2] Losartan (0.6 g/L in their drinking water) prevents elastic fiber fragmentation and blunted TGF-β signaling in the aortic media in pregnant Fbn1C1039G/+ mice, as evidenced by reduced nuclear accumulation of pSmad2. Losartan (0.6 g/L in their drinking water) shows a reduction in ...
The cellular and signaling changes seen in post-MI valves support the hypothesis that these profibrotic processes are therapeutically accessible. Specifically, as an initial approach, modulation by TGF-β inhibition seems reasonable based on the overexpression of TGF-β in tethered valves post-MI (2)...
TGF beta/Smad TGF beta/Smad BMP/TGF beta Receptor PKC ROCK TGF β/Smad Wnt/Stem Cell Wnt/Stem Cell Beta catenin BMI1 Casein Kinase Gamma secretase Gli GSK3 Hedgehog Hippo JAK Notch Oct3/4 PKA Porcupine ROCK Stat TGF β/Smad Wnt 首页...