Definitive radiotherapy plus concurrent chemotherapy has been a standard treatment for esophagus patients who are unfit to undergo surgery. However, there are a variety of concurrent chemotherapy regimens with varying efficacy. In this phase II prospecti
After consideration of the long-term side effects elicited by radiotherapy, several studies have endeavored to explore the role of neoadjuvant chemotherapy (nCT) as monotherapy. In the FOWARC study, though the neoadjuvant with mFOLFOX6 alone achieved a postoperative pCR rate of 6.6%, the rates of...
advanced rectal cancer (UICC stage II鈥揑II) were investigated, who received neoadjuvant chemoradiotherapy (total adsorbed dose: 50.4 Gy in 28 fractions and two concomitant courses 5-fluorouracil (250 mg/m2/d)/oxaliplatin (50 mg/m2), followed by consolidating chemotherapy (nine courses of FOLFOX4...
Fig. 3. Abdominal computed tomography revealed that the tumor with stable disease after two courses of FOLFOX chemotherapy via the portal vein in October 2011. 3. Discussion Although cooperative multidisciplinary team (MDT) may increase survival time and improve quality of life, the survival benefit...
Marco MR, Zhou L, Patil S, et al; Timing of Rectal Cancer Response to Chemoradiation Consortium. Consolidation FOLFOX6 chemotherapy after chemoradiotherapy improves survival in patients with locally advanced rectal cancer: final results of a multicenter phase II trial. Dis Colon Rectu...
The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not
survival in terms of prognostic factors (initial treatment, age, sex, location, stage, number of lymph nodes resected, and adjuvant chemotherapy). The location was divided into left and right side, and the cutoff value for the number of lymph nodes was set up to 25. All P values were ...
Because early administration of intensive chemotherapy for LARC has more advantages than adjuvant chemotherapy, total neoadjuvant therapy (TNT) has been introduced and evaluated to determine whether it can improve tumor response or treatment outcomes. This study aims to investigate whether short-course ...
Little data are available on the long-term prevalence and consequences of chemotherapy-induced peripheral neuropathy (CIPN), even though the third largest population of cancer survivors is made up of survivors of colorectal cancer. (2) Methods: A multicenter, cross-sectional study was conducted in ...
The results showed that 16% of women had persistent amenorrhea after FOLFOX chemotherapy [25]. Our results show that the chemotherapy-induced risks are low to intermediate for colorectal cancer. However, the risk is intermediate to high if pelvic radiotherapy is added, as already shown by others...