In this study, a natural language processing (NLP) algorithm was developed to identify local reaction associated with tetanusdiphtheria-acellular pertussis (Tdap) vaccine in the Vaccine Safety Datalink.Methods: Presumptive cases of local reactions were identified among members >= 11 years of age ...
The risks of local reaction (per 10,000 vaccinations) were 2.1 for Td, 2.8 for Tdap and 2.0 for Menactra. The local reaction risks did not vary significantly by vaccine, age at vaccination, or receipt of Td vaccine in the past five years. The majority of the confirmed cases were ...