LECITHINSPHOSPHOLIPASESNAKESRabbit erythrocyte phospholipase B (lysolecithin acyl-hydrolase E.C. 3.1.1.5) hydrolyses the lysophospholipids produced in Ringhals cobra venom—treated rabbit erthrocytes and osmotic ghosts by the action of the venom phospholipase A (phosphatide acyl-hydrolase E.C. 3.1....
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2. Site of action: stomach. 3. pH optimum 4.5-5.5. 4. Substrate long-chain triglyceride.' 5. Reaction products: diglyceride, monoglyceride, FFA, glycerol. 6. Bile salts not needed for activity. 7. Enzyme activity high in newborns. 8. Suckine and hieh fat diet stimulate enzvme activitv...
Phospholipase D is found to have a lytic effect on mitochondrial membrane phospholipids both in the presence and in the absence of Ca2+ ions. Low Ca2+ concentrations stimulate the phospholipase D-membrane interaction, thus increasing the efficiency of the enzyme action. The degradation of ...
Thus PPAR-gamma agonist treatment had a powerful, site-specific effect on adipose metabolism and lipid deposition, and greatly impacted the postprandial handling of TG-rich lipoproteins. These depot-specific effects may be mediated by differential regulation of key metabolic genes, including LPL, 11...
The aim was to determine the site of action of agonism and antagonism of the eCB system in regulating a naloxone- precipitated MWD CPA. Considerable evidence implicates the amygdala in the neurocircuitry of the negative reinforce- ment associated with MWD (eg, Koob, 2009a, b). Therefore, we ...
Phospholipasesare ubiquitousenzymesthathydrolyzephospholipids. Based on the cleavage site of the ester linkage in the substrate phospholipids, phospholipases are classified into four major types,phospholipase A(PLA),phospholipase B(PLB),phospholipase C(PLC), andphospholipase D(PLD), which are further...
Fig. 2. Conversion of triglycerides to glycerol and free fatty acids by lipase (Kumar & Ray, 2014). Generally, a lipase exists in two forms: active and inactive form. This characteristic of the enzyme is controlled by a lid-like structure that covers the catalytic site of the enzyme ...
Conformation of micellar phospholipid bound to the active site of phospholipase A2 Transferred NOE techniques have been used to determine the structure of phospholipid analogues bound to the active site of cobra venom phospholipase A2 (PL... Leigh,A.,Plesniak,... - 《Biochemistry》 被引量: 87...
The initial rates remained nearly constant in the initial phase of the hydrolysis, suggesting that the enzyme is surrounded by excess substrate. 展开 关键词: Phospholipase A 2 Phosphoglyceride hydrolysis Active site inhibition Rat liver mitochondrion ...