Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately results in relapse. This residual disease is often characterized by non-genetic adaptive resistance, that in melanoma is characterised by altered metabolism. Here, we examine...
Evidence suggests that a local breakdown in trophic support and anti-inflammatory cellular communication during the early stages of neurodegeneration plays a critical role in MS progression [3]. Disruptions in these essential interactions between neurons, glial cells, and immune cells can lead to an i...
The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth Article Open access 01 June 2017 The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells Article Open access 17 February 2016 A HIF-1α inhibito...
The low oxygen tension at the site of neoplastic growth has a significant effect on the metabolic status of the cells involved. In order for the cells to survive the harsh conditions of low oxygen and nutrition, the metabolism of the cell switches from an aerobic type of metabolism to an ...
Small-molecule inhibition of PD-1 transcription is an effective alternative to antibody blockade in cancer therapy. Cancer Res. 78, 706–717 (2018). CAS PubMed Google Scholar Ghosh, A. et al. Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-...
To gain insight into the functional and metabolic consequences of glucose oxidation in ECs, we analysed the function of the pyruvate kinase (PK) isozyme PKM2, which has been associated with aerobic glycolysis and growth in cancer cells10,11, and the maintenance of mitochondrial function in diabetic...
Colitis-associated cancer (CAC) is a subtype of colon cancer that is driven by chronic inflammation and is prevalent in chronic ulcerative colitis patients. The development of CAC is associated with the inflammation-dysplasia-carcinoma pathway which is significantly different than adenoma-carcinoma pathwa...