Living with Huntington`s disease: Illness perceptions, coping mechanisms, and spouses' quality of life. International Journal of Behavioral Medicine, 9(1), 37-52.Helder DI, Kaptein AA, Van Kempen GM, Weinman J, Van Houwelingen JC, Roos RA. Living with Huntington's disease: illness ...
L.B., Van Der MeerE., Van DuijnR., WolterbeekA., Tibben
An intellectually active lifestyle—in other words, the so-called cognitive reserve—has a protective effect on the progression and severity of the symptoms of motor, cognitive and psychiatric impairments in Huntington's disease. This severe neurodegenerative pathology of genetic origin can appear in a...
Most unaffected people in the general population have less than 30 CAG repeats, whereas individuals with Huntington's disease usually have 40 or more CAG repeats. The more CAG repeats a person inherits, the earlier the symptoms of Huntington's disease tend to present. The paper, "A genetic as...
VICO addressing severe neurological diseases at the source with RNA modulating therapies Closely-held VICO Therapeutics is developing antisense oligonucleotide (ASO) RNA modulating therapies for patients with severe genetic neurological diseases, including Huntington’s disease (HD) and spinocerebellar... Janu...
Background: There is a need for patient-reported outcome measures that capture the impact that motor impairments have on health-related quality of life in individuals with Huntington's disease. Objectives: The objectives of this study were to establish the reliability and validity of new physical ...
The selection shadow hypothesis states that aging is a collection of detrimental traits that are expressed at the late age, irrelevant for selection. In his book “New Paths in Genetics,” Haldane discusses Huntington’s disease, an autosomal dominant inherited disorder that usually strikes between ...
Design of an Adaptive Randomized Controlled Phase 1b/2a Trial of WVE-003 in Participants with Huntington’s Disease (Danlin Xu, PhD, Medical Director atWave Life Sciences) Poster Available On Demand About Huntington’s Disease Huntington’s disease (HD) is a debilitating ...
How many? How big? How fast? These were the only questions that mattered. Ditching school on Friday continued into the winter. Alpine starts. Three hours north to Mount Washington in New Hampshire. Ice climb Huntington’s. Ski Tuckerman’s. All day. Then back to Boston. ...
Huntington’s disease (HD) is a currently incurable and, ultimately, fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion within exon 1 of the huntingtin (HTT) gene, which results in the production of a mutant protein that forms inclusions and selectively destroys neurons ...