lichen sclerosusvulvar cancercancer riskMalignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection.International Journal of Cancer =: Journal International du Cancer...
Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with a risk of cancer. Its etiology is unknown, possibly involving immune dysregulation and inflammation. Methods Study used DNA methylation (DNAme) and single-cell RNA sequencing...
In three of the patients-two with the diagnosis of lichen sclerosus and one with Bowen's disease-who were first treated with total skinning vulvectomy, the histopathological examination revealed invasive cancer. They were treated again with total radical vulvectomy.In all cases less than 200 ml ...
lymphocyticinflammatory infiltrateis present. Colloid bodies may form from degeneratedkeratinocytes. Several investigators have reported an association of lichen planus with vulvar cancer[32,33]. Although the exact risk ofmalignancyis not known, their coexistence with lichen sclerosis suggests a similar ...
Sepia:Sepia is indicated when there are distinct white patches on the skin. The cause of Lichen sclerosus can be hormonal changes, especially during menopause. There is the sensation of heaviness or pressure in the pelvic region, which may be linked to the chronic inflammation of the skin. The...
Natural Remedies for Lichen Sclerosus: Insights from Earth Clinic Readers 1. Apple Cider Vinegar (ACV) Many Earth Clinic readers swear by the use ofapple cider vinegarfor its anti-inflammatory and antibacterial properties. Diluting ACV with water and applying it to the affected areas can help redu...
Practice Gaps "Down There": Failures in Education, Physical Examination, Recognition, Diagnosis, Therapy, Follow-up Care, and Cancer Surveillance in Lichen... Margesson L (2013) Practice gaps"down there": failures in education, physical examination, recognition, diagnosis, therapy, follow-up care...
Cancer detectionIn vivo imagingFiber Bragg gratingsLight sourcesSignal detectionVisualizationLichen sclerosus (LS) is a chronic inflammatory skin condition that has a predilection for the anogenital skin in women. The true prevalence of vulvar LS is unknown, underdiagnosed, and underreported [1]. ...
ImportanceThe molecular mechanism leading to the development of vulvar squamous cell carcinoma (VSCC) from vulvar lichen sclerosus (VLS) is unknown. ObjectiveTo assess the possible involvement of theIRF6tumor-suppressor gene in the development of VSCC from VLS. ...
What is the risk of developing cancer in patients with lichen sclerosus? Which aspects of lichen sclerosus should be measured to assess response to treatment? Can lichen sclerosus be prevented from occurring and what are the trigger factors?