Andrea is a 49 year old wife and mother who has leukemia. She needs YOU to get tested to see if you are a stem cell donor by getting a quick cheek swab.
The realization in the 1990s that allogeneic stem cell transplants (SCT) have a potentially curative graft-versus-leukemia (GVL) effect in addition to the antileukemic action of myeloablative conditioning regimens was a major stimulus for the development
1, 2, 3, 4 Several elements contribute to the success of HSCT. The conditioning therapy preceding the transplant prepares the recipient (host) to accept the graft, and reduces tumor load. The infusion of healthy allogeneic hematopoietic stem cells restores hematopoiesis and installs an ...
Small Lymphocytic白血病淋巴细胞慢性淋巴瘤CLL, one of the most prevalent lymphoid malignancies in North America and Europe, is the cause of death in most patients with the disease [1]. Standard therapies are often effective but are non-curative. Allogeneic hematopoietic stem cell transplant (AHCT)...
Earlier, allogeneic transplantation of CML was a profound success, particularly in chronic phase. Reduced-intensity or non-ablative transplant approaches have also been developed in an attempt to avoid the toxicities of high-dose preparative regimens while retaining the potentially powerful graft-versus-...
The authors also emphasize the importance of consolidating when possible with an allogeneic stem cell transplant, in light of the poor prognosis (median overall survival of 8.7...doi:10.1016/j.bbmt.2014.11.467Saranya KodaliEswar Tipirneni
OS overall survival RFS relapse-free survival SCT stem cell transplant TTE time-to-event WBC white blood cell Keywords AML Leukemia Clinical trial Endpoint 1. Introduction Although a few new drugs have been approved for acute myeloid leukemia (AML) based on improved survival vs standard therapy in...
(MRD) were MRD negative. Additionally, 63% (36/57) of the efficacy-evaluable patients achieved an overall response, 39% (14/36) of whom underwent hematopoietic stem cell transplant (HSCT), with 50% (7/14) restarting revumenib as pos...
Allogeneic stem cell transplantation is still the only curative option in high risk and relapsed AML, but morbidity and mortality are high owing to transplant-related side effects and refractory disease [2]. Targeted immunotherapy provides a potent option to specifically eliminate chemoresistant leukemic...
Allogeneic stem cell transplantation for patients with acute myeloid leukemia (AML) in second complete remission (CR2) transplanted from unrelated donors with post-transplant cyclophosphamide (PTCy). A study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Tr...