In some patients, persistent GERD also stimulates immature progenitor cells in the distal esophagus to differentiate into intestinal cell types that constitute the specialized intestinal metaplasia characteristic of Barrett's esophagus. The metaplasia that occurs in Barrett's ...
Loss ofCDKN2Ais known to drive the progression of several cancers, including esophageal adenocarcinoma (EAC). Genetic analyses of samples of Barrett’s esophagus (EAC precursor condition) show that early loss ofCDKN2Adelays EAC initiation. Moreover, the concomitant loss of other genes in the same ...