A two-step process for manufacturing d,l- beta -benzoylamino-isobutyric acid is disclosed, wherein in the first step benzamide is reacted with methacrylonitrile in the presence of an alkaline catalyst in an anhydrous solvent medium at atmospheric pressure, thus obtaining d,l- beta -benzoylamin...
A two-step process for manufacturing d,l- beta -benzoylamino-isobutyric acid is disclosed, wherein in the first step benzamide is reacted with methacrylonitrile in the presence of an alkaline catalyst in an anhydrous solvent medium at atmospheric pressure, thus obtaining d,l- beta -benzoylamin...
clozapine; L-β-aminoisobutyric acid; astrocyte; microdialysis; schizophrenia1. Introduction Clozapine is well established as one of the most effective antipsychotic agents and effective in the treatment of antipsychotic-resistant schizophrenia, as demonstrated by various meta-analyses [1,2,3,4,5]; ...
A two-step process for manufacturing d,l- beta -benzoylamino-isobutyric acid is disclosed, wherein in the first step benzamide is reacted with methacrylonitrile in the presence of an alkaline catalyst in an anhydrous solvent medium at atmospheric pressure, thus obtaining d,l- beta -benzoylamin...