K V channel activation leads to membrane hyperpolarization, resulting in inhibition of voltage-dependent calcium (Ca 2+ ) channels, a reduction in intracellular Ca 2+ concentration ([Ca 2+ ] i ) and vasodilation. In contrast, K V channel inhibition leads to membrane depolarization and ...
Thus, we anticipated an increased λ by inhibition of voltage-activated K + channels. Application of the BK Ca channel blocker iberiotoxin (100nM) onto mesenteric arterioles in vitro and inhibition of BK Ca channel current in silico increased λ by 34% and 32%, respectively. Similarly, ...
K+channels are differentially expressed throughout oligodendrocyte (Olg) development. Kv I family voltage-sensitive K+ channels have been implicated in proliferation and migration of Olg progenitor cell (OPC) stage, and inward rectifier K+ channels (KIR)4.1 are required for OPC differentiation to mye...
Elucidating the fundamental mechanism of voltage-dependent gating of KVchannels remains an important goal of basic biomedical research. After decades of structural and functional studies, processes such as VSD activation are now relatively well-understood. However, E–M coupling remains poorly understood,...
We conclude that IK(V), the predominant voltage-gated outward current in H9c2 myoblasts, flows through the channels comprised of the K(V)2.1-subunit gene product. 展开 关键词: outward K^+ current tetraethyl ammonium quinidine mRNA expression H9c2 cell line ...
Kv1.1 and Kv1.2 knockout mice both have seizures beginning early in development; however, each express a different seizure type (pathway), although the channels are from the same subfamily and are abundantly coexpressed. Voltage-gated ion channels clustered in specific locations may present a ...
Changed expression of Delayed rectifier (Kv1.1, Kv1.6) Kv channels and A-type potassium channel (Kv1.4) in the aged gerbil hippocampus 喜欢 0 阅读量: 23 作者: Su-Jeong,Jeon,Ji-Heon,Jeong,Yeon,Hee,Yu,Dae-Kyoon,Park,Kyung-Ho,Park,Jeong-Sik,Ko,Duk-Soo,Kim 展开 ...
A human Kv3.3 mutation within a conserved proline-rich domain produces channels that bind Hax-1 but are impaired in recruiting Arp2/3 to the plasma membrane, resulting in growth cones with deficient actin veils in stem cell-derived neurons. Graphical Abstract Download: Download high-res image ...
Studies the inhibitory effects of endothelin 1 on voltage-gated potassium (Kv) channels in hypoxic hypertensive rat pulmonary artery myocytes. Cell isolation and myosin staining; Effect of chronic hypoxia on voltage-gated postassium current; Role of ET-1-mediated pulmonary artery vasoconstriction in ...
Successful functional insertion of the HAP sequence into the S1-S2 linker ofKV4.2suggests that other related channels may similarly be amenable to this tagging strategy. 展开 关键词: KV4.2 S1-S2 loop alpha-bungarotoxin trafficking ion channel mutagenesis ...