Autism spectrum disorder TMLHE: Trimethyllysine hydroxylase epsilon gene TMLD: N6-trimethyllysine dioxygenase WT: Wild-type Tmlhe-KO: Trimethyllysine hydroxylase epsilon gene knockout mice OCTN2, SLC22A5: Organic cation transporter novel type 2 GBB: γ-Butyrobetaine UPLC‒MS/MS: Ultra-perf...
Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is showi
There was a significant correlation between N1 latency and sociability but not between N1 latency and premating USV power or T-maze performance. The increases in N1 latency, impaired sociability, and reduced vocalizations in PV-selective NR1 KO mice mimic similar changes found in autism. ...
Decades of intensive research have provided little knowledge and understanding of the biological changes underlying severe psychiatric disorders, in particular schizophrenia and autism. One advancement has come from genome-wide association studies that identified hemizygous microdeletions and microduplications term...
The 15q13.3 microdeletion increases the risk of intellectual disability, epilepsy, autism spectrum disorder and schizophrenia, though the clinical profile varies considerably. Two mouse models of this syndrome, with hemizygous deletion of the orthologous region in the murine genome, have recently been ...
37]. Ikezu et al. found that transient depletion of microglia caused by the CSF1R inhibitor PLX5622 can improve social impairment and stereotyped repetitive behavior in autism model mice with poly I:C-simulated maternal immune activation [38]. Interestingly, Elmore et al., who first discovered ...
摘要: Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders which begin in childhood and persist into adulthood. They cause lifelong impairments and are associated... 查看全部>>关键词:ASDs ADHD USVs social behavior repetitive behavior ...
Study Objectives: Neuroligin-3 (NLGN3) is one of many genes associated with autism spectrum disorder (ASD). Sleep dysfunction is highly prevalent in ASD, but has not been rigorously examined in ASD models. Here, we evaluated sleep/wake physiology and behavioral phenotypes of rats with genetic ...
doi:10.1186/s13229-023-00560-7N6-trimethyllysine dioxygenase (TMLD)Autism spectrum disorderMiceGamma-butyrobetaineMitochondriaDeletion of exon 2 of the trimethyllysine hydroxylase epsilon (TMLHE) gene was identified in probands with autism spectrum disorder (ASD). TMLHE encodes the first enzyme in ...
Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is showing severe autism related core symptoms, as ...