Additionally, data using an IL-9 reporter mouse showed that significant amounts of IL-9 were produced by ILC2s rather than Th9 cells (Wilhelm et al., 2011). Thus, the importance of TGFβ-mediated induction of Th9 cells is not clear. 2.1.2.10 TGFβ-Mediated Regulation of CD4 + T ...
and this interaction between KLRG1 and E-cad inhibits the proliferation and cytokine production of type 2 innate lymphoid cells (ILC-2s) [49]. The
and this interaction between KLRG1 and E-cad inhibits the proliferation and cytokine production of type 2 innate lymphoid cells (ILC-2s) [49]. The
We established that lung ILC2s express a functionally active AR that can be in vivo targeted with exogenous androgens to negatively control ILC2 homeostasis, proliferation, and function. Androgen signaling upregulated KLRG1 on ILC2s, which inhibited their proliferation on E-cadherin interaction. ...
Immunotherapy for Upper Airway Disease Generates IL-10-Producing KLRG1 + ILC2s that are Associated with Clinical Benefitinnate lymphoid cellsepithelial barrierallergic rhinitisallergen immunotherapySummaryIn this study, we addressed the role of IL-10-producing ILCs in controlling grass pollen allergy. IL-...