In the FinnGen consortium, patients with kidney stones were defined by N20 in the International Classification of Diseases, 10th Revision (ICD-10) and 592 in ICD-8 and ICD-9. This GWAS was performed on 5,985 cases and 253,943 controls with the adjustment for sex, age, first ten ...
Kidney stones affect ~20% of men and ~10% of women by 70 years of age1and commonly cause debilitating pain. The prevalence of this disorder is increasing and the United States is predicted to spend over $5 billion per year by 2030 on its treatment2. Unfortunately, up to 50% of individ...
Kidney stonesUTIUrolithiasisUrinary tract infectionPurpose To describe risk of UTI in Stone formers comparing to non-stone formers. Methods Retrospective cohort study using electronic records for patients across southern England. Stone formers referred to a tertiary referral centre in Southern England, ...
Kidney stones ○ Hypertension ○ Renal cystsmay be discovered, even onprenatal ultrasound. • ARPKD ○ Parents unaffected ○ Respiratory distress ○ Oligohydramnios ○ Spontaneous pneumothoraces ○ Severe hypertension ○ Portal hypertensionwith age ...
Conversely, we did not anticipate eGFR to be associated with the risk of gallstones or cholecystectomy (ICD-10 codes K80 + K81 and JKA21 + JKA20) or car accidents (Z04), which were selected as negative control outcomes. To address the possibility of reverse causation (e.g., that ...
The risk factors for kidney cancer have been categorized as: (a) life style risk factors—tobacco smoking, excess body weight, alcohol consumption, physical activity and diet; (b) medical history—hypertension, chronic kidney diseases, kidney stones, and diabetes mellitus; (c) environmental and ...
While 24-h urine calcium excretion increased on average ∼50 mg·day−1 greater than placebo, there was no greater risk of clinical nephrolithiasis, though pre-existing kidney stones were an exclusionary criteria for trial randomization. Serum uric acid did rise significantly more than placebo, ...
The mendelian randomization effect of genetic proxies of thiazide diuretics on kidney stones was estimated in the MVP, UKB, and FinnGen individually (eTables 6-9 in Supplement 1) and then combined in a random-effects meta-analysis (eTable 10 in Supplement 1). In the meta-analysis, genetic ...
day21 greater than placebo, there was no greater risk of clinical nephrolithiasis, though pre-existing kidney stones were an exclusionary criteria for trial rando- mization. Serum uric acid did rise significantly more than placebo, though the clinical consequences of this change in serum uric acid...
We assessed comorbidities and co-medications in the claims during the 12 months before the treatment initiation using ICD-9-CM diagnosis and procedure codes and 11-digits national drug codes (NDC), including: other kidney disease, proteinuria, kidney stones, hypercalciuria, diabetes mellitus, cardiova...