非奈利酮在其他方面也具有良好的耐受性,在2个大型试验中未发现严重AKI的额外风险。更多详情参见KDIGO 2022慢性肾脏病糖尿病管理临床实践指南。 与单独使用SGLT2i和非奈利酮相比,评估SGLT2i和非奈利酮联合使用效果的试验正在进行中(Clin-icalTrials.gov:NCT05254002)。尚未对与无糖尿病的CKD患者进行类固醇和nsMRA的有效...
that measures to reduce the rate of kidney function deterioration be included as part of holistic management, such as optimal blood pressure control, the use of renoprotective medications, avoidance of nephrotoxic insults, and prevention of circumstances that may result in acute kidney injury (AKI)....
Practice Point 1.1.3.2: Do not assume chronicity based upon a single abnormal level for eGFR and ACR, as the finding could be the result of a recent acute kidney injury (AKI) event or acute kidney disease (AKD).Practice Point 1.1.3.3: Consider initiation of treatments for CKD at first ...
The most worldwide used classification system for staging AKI is KDIGO-2012, it was based on a combination of the RIFLE and AKIN criteria. KDIGO severity stages are defined: Stage 1 ↑ in SCr by >0.3 mg/dl or increase in SCr to >1.5x baseline. Stage 2 ↑ in SCr ≥2.0–2.9x ...
专家提示,患者的监测计划应当是个体化的。监测计划不仅与药物的使用情况,即处方相关,也与患者的自身情况相关。如急性肾损伤(AKI)、癌症和怀孕都可能影响监测的指标和频率(图2)。 图2 如何设计个体化监测计划 同时,应注重避免处方级联。处方级联是指处方给患者一种药物,引起了不良事件体征和症状,为处理这些不良事件体...
非奈利酮在其他方面也具有良好的耐受性,在2个大型试验中未发现严重AKI的额外风险。更多详情参见KDIGO 2022慢性肾脏病糖尿病管理临床实践指南。 与单独使用SGLT2i和非奈利酮相比,评估SGLT2i和非奈利酮联合使用效果的试验正在进行中(Clin-icalTrials.gov:NCT05254002)。尚未对与无糖尿病的CKD患者进行类固醇和nsMRA的有效...