Objective To investigate the effect of rocuronium and vecuronium on K + channel in neuromuscular junction of rat diaphagm. 目的利用成年大鼠膈肌膈神经不均匀牵拉标本,探讨罗库溴铵和维库溴铵对神经肌肉接头部位钾离子通道的影响。 2. Aim and Methods: To observe the effects of Puerarin on K + channel...
1999). In analogy with Nrx-IV and glycophorin C, it is likely that the localization of Caspr2 to the juxtaparanodal region may also involve a complex interaction with cytoplasmic proteins, such as members of the protein 4.1 family and PDZ domain–containing proteins. Possible Function of Caspr...
Background and purpose: The role of inosine at the mammalian neuromuscular junction (NMJ) has not been clearly defined. Moreover, inosine was classically considered to be the inactive metabolite of adenosine. Hence, we investigated the effect of inosine on spontaneous and evoked ACh release, the ...
(8,25,35). These proteins contain multiple protein–protein interaction domains and appear to function as a scaffolding that organizes signaling molecules at membrane junctions (40,3,28). Our work shows that membrane association of PSD-95 is not only mediated by its protein interaction motifs ...
Because neither caffeine-induced tensions in intact fibers nor contractile protein and sarcoplasmic reticulum function in skinned fibers were modified by quaternary ammonium ions, their site of action appears to be limited to surface or transverse tubular system membranes, or both. The unique tensions ...
Chen F, Sugiura Y, Myers KG, Liu Y, Lin W (2010) Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction. Proc Natl Acad Sci USA 107(4):1636–1641. doi:10.1073/pnas.0911516107 CrossRef Yamazaki K, Wakasugi N, Tomita ...
P-type ATPases pump ions across membranes, generating steep electrochemical gradients that are essential for the function of all cells. Access to the ion-b... A Takeuchi,N Reyes,P Artigas,... - 《Channels》 被引量: 127发表: 2008年 Non-quantal release of transmitter at mouse neuromuscular...
Loss-of-function experiments demonstrated that two components of the sieve plate, moesin and annexin II, were positive and negative regulators of fenestra formation, respectively. Biochemical analyses showed that moesin is involved in the formation of an actin–fodrin submembrane cytoskeleton that was ...
Introduction:Acute ischemic stroke (AIS) triggers endothelial activation and induces cerebrovascular inflammation which can result in vascular function and... Trevor S Wendt,Rayna J Gonzales - Stroke 被引量: 0发表: 2024年 Percutaneous Access to Cervical Fistulas of the Thoracic Duct: A New Approach...
(Traka et al., 2002). To investigate the possible involvement of TAG-1 in Caspr2 function, we compared its expression along myelinated nerves in wild-type and Caspr2-/- mice. Staining of teased sciatic nerves of wild-type animals using a pAb to TAG-1 and an mAb to Na+ channels ...