Background and purpose: The role of inosine at the mammalian neuromuscular junction (NMJ) has not been clearly defined. Moreover, inosine was classically considered to be the inactive metabolite of adenosine. Hence, we investigated the effect of inosine on spontaneous and evoked ACh release, the ...
Local function of the Notch gene for embryonic ectodermal pathway choice in Drosophila. Mutations at the Notch locus affect the fate of cells in the neurogenic region of the Drosophila embryo so that epidermal precursors become neuroblasts. We... PE Hoppe,RJ Greenspan - 《Cell》 被引量: 174发...
This is summarized in Fig. 1. The importance of this function is reflected in estimates that sug- gest it accounts for roughly 50% of the total brain energy consumed (Erecinska and Silver 1994). This action of the pump results in the cell losing net positive charge, becom- ing more...
K$^{+}$-channel Blockers Restore Synaptic Plasticity in the Neuromuscular Junction of Dunce, a Drosophila Learning and Memory Mutant The effects of K$^{+}$-channel blockers on synaptic transmission in dunce (dnc), a Drosophila learning and memory mutant, were investigated. Larvae dnc mut......
F-M: Analyses of motor function in SOD1G93A mice treated with TRAM-34 (black dots) or vehicle (white dots) with: hanging wire test, score (F) and latency (G), inverted grid test (H), rotarod test (I), grip strength test (force) (L) and extension reflex (M). Behavioral tests ...
1999). In analogy with Nrx-IV and glycophorin C, it is likely that the localization of Caspr2 to the juxtaparanodal region may also involve a complex interaction with cytoplasmic proteins, such as members of the protein 4.1 family and PDZ domain–containing proteins. Possible Function of Caspr...
Objective To investigate the effect of rocuronium and vecuronium on K + channel in neuromuscular junction of rat diaphagm. 目的利用成年大鼠膈肌膈神经不均匀牵拉标本,探讨罗库溴铵和维库溴铵对神经肌肉接头部位钾离子通道的影响。 2. Aim and Methods: To observe the effects of Puerarin on K + channel...
Na,K-ATPase activity is critical for maintaining electrogenesis, contractile function and skeletal muscle performance. This review is devoted to the analysis of the results of recent studies in the field of molecular and functional diversity of Na,K-ATPase in skeletal muscles, which co-express α...
Nodes of Ranvier | Definition, Structure & Function from Chapter 11 / Lesson 29 156K Understand what the Nodes of Ranvier and their functions are. Explore the structures of the Nodes of Ranvier, together with the other parts of the neuron. Related...
Rather than regulating channel activity, interaction with PSD-95 may primarily function to target Kir to specific synaptic sites. PSD-95 has a modular domain structure consisting of three N-terminal PDZ domains, followed by an src homology-3 (SH3) motif often involved in binding to cytoskeleton...