Groß et al. report that the topical immunomodulator imiquimod and the related molecule CL097 trigger K+efflux-independent NLRP3 activation by targeting the ROS-producing quinone oxidoreductases NQO2 and mitochondrial Complex I. DOI: 10.1016/j.immuni.2016.08.010 被引量: 21 年份: 2016 ...
The kinetics of K+ efflux was investigated in the membranes of frog sartorius muscle after disintegration by glycerol treatment. Data of the K+ concentration in the muscle as a function of time of the glycerol treatment fitted well the sum of two exponential fractions (with the correlation coeffi...
Therefore, we first normalized the shift of VrevK+ to K+ efflux by plotting tail K+ currents as a function of the quantity of K+ ions (quantity of charge, Q; see Materials and Methods) exiting the hair cell in response to different Vconds (usually from −14 mV to 36 mV). ...
Because of this difference, we sought a surrogate or precursor lesion that leads to hemolysis, and potassium efflux has been observed from erythrocytes treated with other pore-forming toxins. AC toxin elicits an increase in K+ efflux from sheep erythrocytes and Jurkat cells, a human T-cell ...
In guinea-pig ileal longitudinal smooth muscle, both palytoxin (PTX) and carbachol (CCh) increased K+ efflux with an EC50 of 1.8 X 10(-10) M and 4.1 X 10(-7) M, respectively. Atropine (10(-6) M) did not inhibit the K+ efflux due to PTX (3 X 10(-9) M), but completely in...
ZMK2 stabilizes the membrane potential by balancing the H+ influx by K+ efflux. Under these conditions, the depolarization of the membrane potential through ZmSUT1 is not prevented by coinjection of ZmSUT1 with the inward rectifierKZM1. The tip region of the maize leaf contains the oldest ...
14. K+efflux from plant cells is also involved in the adjustment of intracellular K+homeostasis in response to altered environment conditions15. To deal with K deficiency, plants have evolved two major mechanisms to maintain K+homeostasis in plant cells, one is K+acquisition from the soil and ...
Further estimation by ion content and micro-electrode ion flux indicated a relative weaker K+ efflux in the OE-LrKUP8 calli than in the control. Thus, a key gene involved in K+ uptake under salt condition was functionally characterized using a newly established L. ruthenicum callus ...
On the other hand, noise-induced hair cell and auditory nerve excessive-excitation increases K+ efflux from hair cells and nerve fibers, which can elevate extracellular (perilymphatic) K+ concentration causing K+ excitotoxicity. Noise can also impair the reticular lamina integrity breaking the barrier...
+ efflux from adult type I vestibular HCs remain to be identified (with a likely contribution of erg channels (8)), we propose that K+ is removed from the cleft through postsynaptic KCNQ4, KCNQ5, and possibly Kir4.1 K+ channels, which were also found in type I HC calyces (...