In three of the studies with cognitively impaired (including Alzheimer's disease (AD)) samples, the interventions had a beneficial effect on cognitive outcomes but only in participants with mild cognitive dysfunction [23, 25, 28]. This finding was not replicated in a large RCT conducted over 18...
Genome wide association studies, transcriptomic analyses, and epigenomic studies all implicate microglia in the pathogenesis of adult-onset and age-related neurological diseases, such as Alzheimer’s disease [11], Parkinson’s disease [12] and Multiple Sclerosis [13]. Finally, heterozygous mutations ...
Alzheimer’s disease-associated protective variantPlcg2-P522Rmodulates peripheral macrophage function in a sex-dimorphic manner Hannah A. Staley, Janna E. Jernigan, MacKenzie L. Bolen, Ann M. Titus, Noelle Neighbarger, Cassandra Cole, Kelly B. Menees, Rebecca L. Wallings and Malú Gámez Tanse...
DLQI reflects the QoL during treatment, which is a subjective score of the patient [17, 55]. Till now, only a few studies have reported the roles of PUFAs in improving QoL in other diseases, such as inflammatory bowel disease and Alzheimer’s disease [56, 57]. While in the context of...
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In contrast, cerebrospinal fluid TMAO levels have been indicated as predictive of cognitive decline in Alzheimer’s disease [28], while suppression of microbial TMA/TMAO production improves cognitive function in the murine APP/PS1 model of Alzheimer’s disease [29]. Given the disparities in the ...
Approximately 70% of Alzheimer’s disease (AD) patients have co-morbid vascular contributions to cognitive impairment and dementia (VCID); this highly prevalent overlap of dementia subtypes is known as mixed dementia (MxD). AD is more prevalent in women, while VCID is slightly more prevalent in...
Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease. Arch Gen Psychiatry 2011,68(8):853–861. 10.1001/archgenpsychiatry.2011.72 Article CAS PubMed Google Scholar Tewes U: Hamburg-Wechsler-Intelligenztest für Erwachsene - Revision 1991 (HAWIE-R). Huber, ...
Loneliness and Risk of Alzheimer Disease. Arch Gen Psychiatry. 2007;64(2):234–240. https://doi.org/10.1001/archpsyc.64.2.234. Kogan JH, Frankland PW, Silva AJ. Long-term memory underlying hippocampus-dependent social recognition in mice. Hippocampus. 2000;10(1):47-56. https://doi.org...
Alzheimer's disease (AD) Addition of lovastatin to human HEK cells transfected with the amyloid precursor protein (APP) was shown to reduce intracellular cholesterol/protein ratios by 50%, and to inhibit cleavage of APP by beta-secretase [97]. Non-demented individuals with heart disease have inc...