The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis, immune balance, tissue homeostasis, and ...
2. Walker JG, SMith MD. The Jak-STAT pathwayin rheumatoid arthritis. J. Rheumatol. 2005 Sep;32(9):1650-3. PubMedID:16142855 3. Marrero MB. Introduction to JAK/STATSignaling and thevasculature. Vascul. Pharmacol. 2005 Nov;43(5):307-9. PubMed ID: 16263337 4. Gao B. Cytokines, STATs...
The accurate description of the whole third paragraph (the right column) on Page 8 is as below: For two decades, it was wrongly assumed that the specific receptors of βc family cytokines (IL-3Rα, IL-5Rα, and GM-CSFRα) did not link with JAKs and that signaling of these cytokines ...
2. Walker JG, Smith MD. The Jak-STAT pathwayin rheumatoid arthritis. J. Rheumatol. 2005 Sep;32(9):1650-3. PubMedID:16142855 3. Marrero MB. Introduction to JAK/STATsignaling and thevasculature. Vascul. Pharmacol. 2005 Nov;43(5):307-9. PubMed ID: 16263337 4. Gao B. Cytokines, STATs...
JAK-STAT Cell Signaling Pathway ‹JAK-STAT JAK-STAT Pathway Overview The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a critical role in the signaling of a wide array of cytokines and growth factors. These cytokines and growth factors are respon...
(1)阻断STAT进入受体结合位点 SOCS结合受体上的磷酸化酪氨酸位点,从而物理性阻断STATs与受体的结合。 (2)JAKS失活 SOCS可以直接结合JAKs或受体从而特异性地抑制JAKs激酶活性,使其抑制其对STAT的磷酸化能力。 (3)诱导与之结合的蛋白发生泛素化降解 SOCS与延伸蛋白BC...
The Jak-STAT signalling pathway regulates many cytokines and growth factors. Use the interactive pathway map to find related RayBiotech products.
Mechanistically, JAK/STAT signaling is relatively simple, with only a few principal components. A variety of ligands including cytokines, hormones, and growth factors, and their receptors stimulate the JAK/STAT pathway. Intracellular activation occurs when ligand bin...
3. Marrero MB. Introduction to JAK/STATsignaling and thevasculature. Vascul. Pharmacol. 2005 Nov;43(5):307-9. PubMed ID: 16263337 4. Gao B. Cytokines, STATs and liver disease. Cell Mol. Immunol. 2005 Apr;2(2):92-100. PubMed ID: 16191414 ...
3. Marrero MB. Introduction to JAK/STATsignaling and thevasculature. Vascul. Pharmacol. 2005 Nov;43(5):307-9. PubMed ID: 16263337 4. Gao B. Cytokines, STATs and liver disease. Cell Mol. Immunol. 2005 Apr;2(2):92-100. PubMed ID: 16191414 ...