Brett Favre revealed he's been diagnosed with Parkinson's disease. Here's what to know about the diagnosis.
IMPORTANCE OF THE FIELD: Levodopa (LD) is an efficient drug for patients with Parkinson's disease (PD). Its short half-life supports peaks and troughs. These plasma fluctuations support alternating stimulation of striatal postsynaptic dopamine receptors and thus onset of motor complications. They ...
Under a Creative Commons license open accessHighlights Summary Genetic variants in ABCA7, an Alzheimer’s disease (AD)-associated gene, elevate AD risk, yet its functional relevance to the etiology is unclear. We generated a CRISPR-Cas9-mediated abca7 knockout zebrafish to explore ABCA7’s role...
Apomorphine, adverse reactionsApomorphine, pharmacokineticsApomorphine, therapeutic useDrug-delivery-systemsParkinson's-disease, treatmentTrial-result-clinicalVarious-toxicities, drug-inducedVectura
Parkinson's diseaseSubthalamic nucleusBACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease. However, DBS is not responsive to an individual's disease state, and programming parameters, once established, do not change to reflect disease ...