Well, if a molecule is considered to be a discrete small unit made up of atoms joined together, then NaCl, andany other ionic solid is not really a molecule. In NaCl we have a repetitive crystal structure in which each Na+ion is surrounded by Cl-ions, and vice-versa, for as far as...
Current small-molecule inhibitors of KRAS(G12C) bind irreversibly in the switch-II pocket (SII-P), exploiting the strong nucleophilicity of the acquired cysteine as well as the preponderance of the GDP-bound form of this mutant. Nevertheless, many oncoge
The selective genetic removal of APOE4 from neurons led to a significant reduction in tau pathology, gliosis, neurodegeneration, neuronal hyperexcitability and myelin deficits. Single-nucleus RNA-sequencing revealed that the removal of neuronal APOE4 greatly diminished neurodegenerative disease-associated ...
We carried out a screen for small molecule selective inhibitors of eukaryotic DNA polymerases (pols). Dehydroaltenusin, isolated from a fungus (Alternaria tenuis), was found to be a specific inhibitor of pol α.We succeeded in chemically synthesizing dehydroaltenusin along with five analogs. Of...
The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl- SummaryIn Pseudomonas aeruginosa, diverse exoproduct virulence determinants are regulated via N-acylhomoserine lactone-dependent quorum sensing. Here we sh... Stephen,P...
Here we reconstitute human translation reactions in vitro19to examine the molecular basis of decoding at a high temporal and spatial resolution by combining multiperspective single-molecule fluorescence resonance energy transfer (smFRET) imaging and cryogenic electron microscopy (cryo-EM). Together, these...
PTX3 expression was epigenetically regulated in selected human tumors (e.g., leiomyosarcomas and colorectal cancer) by methylation of the promoter region and of a putative enhancer. Thus, PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic onco...
Isavuconazole (7) is a recently discovered broad-spectrum antifungal pharmaceutically active triazole based drug of the prodrug isavuconazonium sulphate. This antifungal molecule was approved in the US and Europe for treating mucormycosis. In Europe, isavuconazole was approved due to the non-feasibilit...
Because previous clinical trials have indicated that the M40403 molecule is well tolerated in humans, this study may have important implication for the treatment of Parkinson disease. 展开 关键词: Parkinson disease antioxidant oxidative stress superoxide dismutase (SOD) superoxide ion ...
Brolucizumab (Beovu) is a novel anti-VEGF molecule, a humanized single- chain variable antibody fragment (scFv). Compared to aflibercept in eyes with diabetic macular edema (DME). KITE, KESTREL and KINGFISHER, phase III studies found an intraocular inflammation in 2.2% to 4.7% of cases with...