Myelodysplastic syndromes (MDSs) represent clonal disorders mainly of the elderly that are characterized by ineffective hematopoiesis and an increased risk of transformation into acute myeloid leukemia. The pathogenesis of MDS is thought to evolve from a
Colorectal cancer (CRC) is considered a major public health problem and is the fourth most common can- cer and the fifth leading cause of cancer-related death in both sexes worldwide1. Thus, studies of the effects of non-genetic2,3 and genetic risk factors on CRC development4 have ...
Following Rachel Carson’s Silent Spring narrative, environmentalists claimed that, with DDT, cancer deaths would have negated the malaria survival rates. No evidence supported this. It was fiction invented by Carson. The only type of cancer that increased during DDT use in the US was lung ...
screened and removed data separately; mean differences (MDs) had been determined, and results were pooled utilizing a random-effects design. Eleven researches met our qualifications requirements (n=860), of which 9 had been included in the meta-analeadache disorders.Among the arrangements of this...
Both MDs and DOs are licensed to practice in the U.S. and Canada. What is the difference between allopathic and osteopathic medicine? There are two main philosophies in medicine: allopathy and osteopathy. Allopathy: MDs learn allopathy in medical school. This is what is considered “modern me...
Further, the prevalence and clinical implications of CH in patients with non-hematologic cancers have not been extensively studied (Xie et al., 2014). At Memorial Sloan Kettering Cancer Center (MSKCC), we have developed a high-throughput capture-based NGS assay, Memorial Sloan Kettering-Integrated...
Error bars indicate the SD of the mean; p < 0.05 was considered statistically significant. Results AM is expressed in cKit+Sca-1+Lin− fetal liver cells AM expression is ubiquitous; it has been detected in various tissues [1]. In KSL cells derived from fetal liver, we performed a ...
PSCS is generally considered a sign of mitotic exit and spindle checkpoint dysfunction. To further explore this apparent weakness in the SAC function of cenp-metaD, we generated a double mutant of cenp-metaD and a null allele of abnormal spindle (asp). The asp mutation, which...
We have previously shown that mice heterozygous for Npm1 (Npm1+/-) develop a hematologic syndrome with features of human MDS. Here we analyzed Npm1+/- mutants to determine their susceptibility to cancer. Npm1+/- mice displayed a greater propensity to develop malignancies compared with Npm1+/...
Only the primary body part of each ROI exhibited activity levels significantly above zero. (C) Multivariate dissimilarities. The left plots are a multidimensional scaling (MDS) depiction of the representational dissimilarity between the three body parts (green, feet; red, hand; blue, lips) in ...