p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker of differentiated vulvar intraepithelial neoplasia (d-VIN). Histopathology. 2006;48(3):268–74.Liegl B, Regauer S, p53 immunostaining in lichen sclerosus is related to ischaemic stress and is not a marker...
Lichen sclerosus is associated with urethral strictures, meatal stenosis, phimosis, paraphimosis, and penile intraepithelial neoplasia; this is one of the predisposing conditions most closely associated with penile cancer (the other is HPV.)[11][16]A biopsy is suggested as lichen sclerosus is closely...
Many problems like this are best to communicate to your doctor even though they may be embarrassing. A good way to urge yourself on is to write down what it is you wish to ask. Reading the questions off of a piece of paper may be helpful when you actually ask the doctor. ...
Conclusion : d-VIN in LS is rare, while p53 staining is common and best explained as an ischaemic stress response due to poor oxygenation, vasculitis and inflammation rather than as a marker of a precancerous lesion in LS.doi:10.1111/j.1365-2559.2005.02321.xB Liegl...