esophageal myenteric neuronslower esophageal sphincter relaxationmechanosensitive neuronsNa+/Ca2+ exchanger 1Aim Our earlier studies showed that mechanical stretch activates inhibitory motor neurons of the oesophagus; however, the underlying molecular mechanisms are unclear. Here, we sought to examine if Na+...
Siglec-2 negatively regulates BCR signaling by recruitment and activation of SH2-containing phosphatase 1 (SHP-1), which counteracts the phospharylation-mediated activation of signaling molecules by dephosphorylation, and reduces Ca2+ signaling by regulating the activity of the Ca2+ pump PMCA. In the...
Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset Alzheimer’s disease (AD). Conditions of stress or injury induce APOE expression within neurons, but the role of neuronal APOE4 in AD pathogenesis is still unclear. Here
Calreticulin (CALR) is a Ca2+-binding protein that shuttles among cellular compartments with proteins bound to its N/P domains. The knowledge that activation of the human erythropoietin receptor induces Ca2+ fluxes prompted us to investigate the role of CALR in human erythropoiesis. As shown by ...
Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea Cancer Biol. Ther., 13 (13) (2012), pp. 1269-1275 CrossrefView in ScopusGoogle Scholar [16] Y.Z. Van Sebille, R.J. Gibson, H.R. Wardill, J.M. Bowen ErbB small molecule tyrosine ki...
Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, a pluripotent signaling molecule that contributes to common aging-related diseases, and find that its activation by ...
Since the discovery of TMEM16A (anoctamin 1, ANO1) as Ca2+-activated Cl− channel, the protein was found to serve different physiological functions, d
Calcium is a ubiquitous signal molecule that is involved in the control of proliferation and apoptosis. We aimed to investigate if the endoplasmic reticulum (ER) Ca2+-homeostasis is different in lung cancer and normal human bronchial epithelial (NHBE) cells. Methods The intracellular Ca2+-signaling...
We therefore estimated the confinement index L, which relates to the probability that a molecule undergoes confined diffusion in a region of radius R for a period of time t32,33,34. This analysis revealed that a substantial fraction of the mobile mGluR5 trajectories (~40%) undergoes transient...
Exacerbating pressure overload-induced cardiac hypertrophy: novel role of adaptor molecule Src homology 2-B3. Hypertension 66, 571–581 (2015). Article CAS PubMed Google Scholar Oka, T. et al. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte ...