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By contrast, species forming exclusively extracellular symbioses, such as ectomycorrhizae, and those forming associations with cyanobacteria, have lost this signalling pathway. This work unifies intracellular symbioses, revealing conservation in their evolution across 450 million yr of plant diversification. ...
Cancers are caused by genomic alterations known as drivers. Hundreds of drivers in coding genes are known but, to date, only a handful of noncoding drivers have been discovered—despite intensive searching1,2. Attention has recently shifted to the role of altered RNA splicing in cancer; driver...
In 2013, the MVA-BN vaccine was authorised in Canada to be used for protection against smallpox; later, in 2019, it was approved for monkeypox use in Canada and licensed by the FDA for smallpox and monkeypox prevention in high-risk people aged 18 and older in the USA. The MVA-BN va...
Cell Ranger 7.0 introduces support for analyzingFixed RNA Profiling (FRP) Gene Expressiondata. In this case, multiple samples are uniquely tagged withProbe Barcodes, enabling samples to be pooled in a single GEM well and resulting in a Gene Expression library. After runningcellranger mkfastqt...
Table 1Baseline characteristics of 657 ART-exposed active PWID in Vancouver, Canada stratified by plasma HIV-1 RNA viral load (VL) non-suppression, 1996 – 2012 Full size table The first hypothesis evaluated was that incarceration was associated with VL non-suppression independent of relevant confou...
The Supreme Court of Canada has ruled thatdemocratic societies founded on the rule of law require a legal basis for restrictions on rights. Social distancing is essential, as a recent study inThe Lancethas demonstrated. But the validity of bans on assemblies must be "prescribed by law."Reports...
The GM industry claims, based on trial data, that while these variet- ies may be cheaper they do not perform as good as the 'legal' varieties.98 Although officially recognized for having increased produc- tion and farmers' income, Bt cotton, remains highly controversial in India. Among other...
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RAS (KRAS, NRAS and HRAS) is the most frequently mutated gene family in cancers, and, consequently, investigators have sought an effective RAS inhibitor for more than three decades. Even 10 years ago, RAS inhibitors were so elusive that RAS was termed ‘