Ipratropium bromideis an anticholinergic drug used mainly in the treatment of asthma.76Clinical studies using this drug as a nasal spray have shown it to be effective in reducing the severity and duration of rhinorrhea in the common cold77and in NAR, especially in rhinitis of the elderly.78–8...
Khoueir N. Ipratropium Bromide Nasal Spray in Non-Allergic Rhinitis: A Systematic Review and Meta-Analysis. The Laryngoscope. 2023 Dec:133(12):3247-3255. doi: 10.1002/lary.30706. Epub 2023 Apr 17[PubMed PMID: 37067019]
describes aerosol formulations of ipratropium bromide having a hydrogen-containing fluorocarbon propellant that is substantially free of CFCs. The described formulations, however, require a surface-active agent, i.e., surfactant, to stabilize the formulation or lubricate a valve stem when used in ...
Ipratropium bromide, 3α-hydroxy-8-isopropyl-1αH,5αH-tropanium bromide (23.3.6), is synthesized by reacting N-isopropylnoratropine with methyl bromide [18–20]. Sign in to download full-size image This drug exhibits broncholytic action by reducing cholinergic influence on bronchial musculature...