First of all, most of the studies [29–43] focus on small and medium scales, and there is short of habitat quality evaluation at the national scale. The studies mostly analyze the habitat quality evaluation results in the whole study area, but not enough for the spatial inequality patterns ...
1784 High-Quality Whole Genome Sequencing (WGS) of Pancreatic Adenocarcinoma Using Systematic Laser Capture Microdissection (LCM) and Flow Sorting (FS) Sheng-Ben Liang, Faiyaz Notta, Tiera Dookhie, Andrew Brown, Parisa Sairafi, Timothy Beck, Julie Wilson, Dianne Chadwick, Lincoln Stein, John ...
Higher risk of recurrence has been associated with age, tumor size, and mutation of the CTNNB1 gene. We aimed to establish specific criteria to predict the risk of recurrence and help guide individualized surveillance and treatment. Design: We conducted a retrospective cohort study of 51 patients...
509A Conclusions: The diagnostic accuracy of telepathology for FS is good (97%), similar to the conventional method (98%). Therefore, it appears to be a valid alternative, especially when there is an emergent situation to improve the TAT. Additionally, the specialists' diagnoses within their ...
Conclusions: 1) A positive FS of the RM does not always prompt further resection, but negative final margins are often achieved with resection of additional tissue. 2) FS may be underutilized in the surgical management of IPMN. 3) Longer follow-up of a larger cohort of patients is needed ...
Design: Over 31-months, 486 PCFs obtained by EUS-FNA were prospectively submitted for molecular analysis to include KRAS, GNAS, HRAS, NRAS, BRAF, VHL, CTNNB1, TP53, PIK3CA, PTEN and AKT1. For all genes, except VHL, next-generation sequencing was performed with minimal coverage of 500X ...
The negative binomial (NB) model was used to test the significance. The differentially expressed genes were deemed significant if the FDR (False Discovery Rate) was less than 0.05, the gene expression was above the 25th percentile and gene showed > 2-fold change difference between the two ...
To date, little is known about the pathogenesis of NMC or its association with fibromatosis (NMC-Fi). Desmoid–type fibromatosis is associated with CTNNB1 (beta-catenin) mutations, and the canonical Wnt signaling pathway, involving beta-catenin, has been implicated in development of the ...
metastatic 33 75 MYCN Amplified 8 18 Non-amplified 25 57 Regresssion No 27 61 Partial 2 4.5 Total 15 34 Dead 10 23 Conclusions: We identified PTPs that could modulate differentiation and growth of NB cells and found an association between PTPN1 and DUSP5 high expression NB and poor ...