Huang H, Wu X, Ibrahim S, McKenzie M, Chen JY: Predicting drug efficacy based on the integrated breast cancer pathway model. Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on: 4-6 December 2011 2011, 42-45....
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 Chinese patients with breast cancer and systematically analyzed their genomic, transcriptomic, proteomic...
6a), which is involved in the regulation of the oncogenic JAK/STAT3 pathway in anaplastic large cell lymphomas and estrogen receptor-positive breast cancer46,47. As expected, this NCOR2 gene-related ATAC peak predicted sensitivity to Go6976, an inhibitor of the PKC and JAK/STAT3 pathways (Ten...
The functional consequences of BMP signaling depend on the BMP ligand and tissue type. We and others have shown that BMP4 reduces the proliferation of breast cancer cell lines, while simultaneously inducing migration and invasion in a subset of cell lines [9–11]. Similar dualistic effects upon ...
IntClust is a classification of breast cancer comprising 10 subtypes based on molecular drivers identified through the integration of genomic and transcriptomic data from 1,000 breast tumors and validated in a further 1,000. We present a reliable method for subtyping breast tumors into the IntClust...
Other mechanisms could involve TRIM28, the phosphorylation of which was shown to downregulate Mfn2 in response to starvation-induced oxidative stress in breast cancer cells (64). We found TRIM28 to be more oxidized in Calu-1 cells at both 4 h and 24 h AgNPs treatment, but the relationship...
This study focuses on the analysis of miRNAs expression data in a cohort of 181 well characterised breast cancer samples composed primarily of triple-negative (ER/PR/HER2-negative) tumours with associated genome-wide DNA and mRNA data, extensive patient
Therefore, we used an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data integration on genomic models (PARADIGM). We show that massive interleukin ...
Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013;91:205–10. CAS PubMed Google Scholar Yu B, Wang AH, Zhou K, Chai LJ, Liu L. Molecular Pathway of Psoralidin-Induced apoptosis in HepG2 cell line. Chin J Integr Med. 2019;25(10):757–62. CAS PubMed ...
b Pathway-level analysis of each proteomic subtype shows relative pathway activity (represented as t-value) of cancer hallmark gene sets derived from gene set variation analysis (GSVA). Benjamini–Hochberg FDR values are annotated as follows: ***FDR < 0.001, **FDR < 0.01, *FDR <...