The cell-purification techniques employed yielded a population highly enriched for T cells (95%), poor for B cells (5%), and deplete for macrophages. Allostimulation induces the formation of clones of T cells capable of specific cell lysis and the appearance of insulin receptors.J. Harold ...
there is a substantive decrease in the density of insulin receptors in insulin-dependent cells due to a decrease in the synthesis of insulin receptors. This phenomenon, which is referred to as “downregulation,” represents a means by which a cell autoregulates its receptivity to the hormone, an...
Insulin receptors and the molecular mechanism of insulin action First page of article CR Kahn,M Crettaz - 《Diabetes/metabolism Reviews》 被引量: 154发表: 2010年 The mechanism of insulin action. The effect of insulin on the allosteric properties of intracellular haemoglobin 1. The results in thre...
Following initial binding to specific cell surface receptors insulin is internalized in target cells. The fate of the internalized insulin-receptor complexes and how the processes involved are regulated is reviewed. The implications of these events in the effects of insulin on its target cells and in...
This study showed for the first time that insulin effects on all levels of the vascular tree are impaired in patients with insulin resistance. Article CAS PubMed PubMed Central Google Scholar Jialal, I. et al. Characterization of the receptors for insulin and the insulin-like growth factors...
the S597-associated IR remains at the cell surface for longer periods of time than insulin-associated IR, presumably via attenuated internalization32. To compare S597-induced IR signaling across different tissues, we examined the effect of S597 on IR signaling in the liver, epididymal white adipo...
Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell. 1990, 61 (2): 203-212. 10.1016/0092-8674(90)90801-K. Article CAS PubMed Google Scholar White MF: The IRS-signalling system: A network of docking proteins that mediate insulin action. Mol Cell...
The chapter discusses the binding of peptide hormone to receptors and alterations in disease. The biologically important receptors for peptide and catecholamine hormones are largely or entirely on the outside surface of the cell. The number of receptors for each peptide hormone on a cell is finite...
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol. 2004;172(5):3173–80. Article CAS PubMed Google Scholar Goldberg A, Parolini M, Chin BY, Czismadia E, Otterbein LE, Bach FH, Wang H. Toll-like receptor 4 ...
[1] which are based on the idea of trade-offs between these processes. In the animal kingdom the insulin-signalling (IS) pathway is of particular importance [2]. Dietary sugars trigger the production of insulin or insulin-like peptides which are sensed by Insulin receptors at the cell ...