The insulin receptor (IR) is a glycosylated, disulfide-linked homodimer with each monomer being made up of an α chain that is entirely extracellular and a β chain that spans the cell membrane once. From:Handbook of Cell Signaling (Second Edition),2010 ...
L. (1998). Insulin receptor signaling in the beta‐cell influences insulin gene expression and insulin content: Evidence for autocrine beta‐cell regulation. Diabetes 47, 1243-1252.Xu, G.G., Rothenberg, P.L., 1998. Insulin receptor signaling in the beta-cell influences insulin gene expression...
Investigates insulin receptor (IR) signaling in the pancreatic beta-cell and describes how this influences insulin gene expression and insulin content. Increase in insulin-stimulated tyrosine kinase activity; Increase in cellular insulin content in beta-cells that overexpressed the wild-type IR; Indicatio...
Insulin binds and activates a receptor tyrosine kinase, the insulin receptor (IR), at the cell surface1,2,3. The activated IR triggers signaling cascades to control many facets of physiology. Dysfunctional IR signaling causes metabolic disorders such as diabetes, a heterogenous disease whose treatme...
Mol. Cell 12, 1379–1389 (2003). CAS PubMed Google Scholar Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K. & Saltiel, A. R. A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol. Cell. Biol. 18, 872–879 (1998)....
Insulin Receptor-Associated Proteins:Insulin and Receptors: INS, INSL3, IRS1, IRS2, IRS4, SORBS1. Insulin-like Growth Factors and Receptors: IGF1R, IGF2, IGFBP1.SH3/SH2 Adaptor Protein: CBL, GAB1, GRB2, IRS4, NCK1.Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, ...
G protein–coupled receptor signaling regulates beta-cell Ca2+-dependent exocytosis by controlling the size of secretory granules and the levels of F-actin agglomeration (Amisten et al., 2013). Also, glucose may regulate insulin exocytosis in pancreatic beta cells by inducing the expression of exoc...
中文名称:Insulin Receptor Alpha Rabbit Monoclonal Antibody 英文名称:Insulin Receptor Alpha Rabbit Monoclonal Antibody 有效期: 一年 产品类别: 细胞代谢 Insulin Signaling 产品编号 产品名称 产品包装 产品价格 AF2440 Insulin Receptor Alpha Rabbit Monoclonal Antibody 50μl 618.00元 来源 用途 交叉反应性 分子量...
1.Insulin/insulin-like growth factor signalingand pancreatic beta cell apoptosis;胰岛素/胰岛素样生长因子信号转导通路与胰岛β细胞凋亡 6)Insulin like growth factor-1 receptor-NOS-NO signaling胰岛素样生长因子-1受体-NOS-NO信号通路 正规胰岛素 ,短效胰岛素,胰岛素药物名称:胰岛素英文名:Insulin别名: 普通胰岛素...
This chapter describes insulin receptors, receptor antibodies, and the... CR Kahn,KL Baird,JS Flier,... - 《Proceedings of the Laurentian Hormone Conference》 被引量: 239发表: 1981年 SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition structure,...