Of the 15/38 pts (39.5%) with a prior IRAE before 2 years, only 3 late IRAEs (20%) involved the same organ system as the pre-2 year IRAE. Late IRAEs were most commonly dermatologic (26.3%), gastrointestinal (21.1%) and musculoskeletal (18.4%). Of the 38 late IRAEs, 7 (18.4%...
Despite its important role in immune system regulation, the ways in which aberrant TLR7 signaling impacts neurodevelopment is not understood. Here, we used a novel prenatal TLR7 activation regimen, involving administration of a selective TLR7 agonist (imiquimod), to investigate the long-term ...
The number of immunoglobulin A (IgA)-producing cells is reduced within the intestinal immune system of high fat diet (HFD)-fed mice. Frequency and absolute number of IgA-producing B cells (IgA+B220+) and plasma cells (IgA+B220−) within thea,bdistal small intestine LP (SB) (n =...
Aging of the immune system: how much can the adaptive immune system adapt? The competency of the adaptive immune function decreases with age, primarily because of the decline in production of nave lymphocytes in the bone marrow an... NP Weng - 《Immunity》 被引量: 1357发表: 2006年 Seventeen...
Compared to the established scoring system for hip fracture patients, which includes PLR and SII b, c, NLR (a) demonstrated the highest accuracy in predicting postoperative pneumonia. ROC refers to receiver operating characteristic; AUC represents the area under the curve; NLR refers to neutrophil-...
such as the promotion of immune tolerance and the correction of shortcomings of the offspring’s immune system5,6,7,8,9,10. For example, in mouse offspring genetically deficient for distinct immune markers, MMc have been described to substitute this shortage, e.g., by secreting IgG in B-...
The bar chart is colored according to their sharing by the 3 lineages. (F) Comparison of effect estimates of top eVariants between healthy volunteers and IMD patients. Results of 20 cell types are plotted together (STAR Methods). (G) The number of IMD-specific eQTLs in each cell subset. ...
Thousands of liters of non-sterile air pass through the pulmonary system every day, but the lungs are, for the most part, maintained inflammation and pathogen free. Although it has been suggested that inhaled bacteria are mostly filtered through the upper respiratory tract and the conducting airwa...
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(due to prolonged survival) with HIV. Children born to HIV-infected mothers—perinatally exposed to HIV—particularly those who eventually acquire the infection, are at risk of acquiring diseases associated with a compromised host immune system, including opportunistic infections5,6. In children and ...