Immune Checkpoint Blockade: InestimAble Advances-免疫检查点阻断:前景不可估量 在过去的十年里,随着调节T细胞反应研究的不断突破,为免疫检测点阻断单克隆抗体(mAbs)的发展提供理论基础,不断攻克癌症治疗的难题。尽管还存在疗效差异(10%到90%)...
中文摘要- immune checkpoint blockade immunotherapy 检查点阻断（checkpoint blockade）是一种利用免疫反应来治疗癌症的强大新策略。溶瘤病毒疗法则是利用病毒来消灭肿瘤的一种干预疗法。来自Ludwig癌症研究中心的一项研究表明联合两者将有可能大大提高临床疗效。检查点阻断（checkpoint blockade）是一种利用免疫反应来治疗癌症...
近日,复旦大学和纽约大学的Kwok-Kin Wong、陈海泉、李飞教授团队联合国内外多家研究机构在 Science Advances 杂志发表了题为Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer的研究性文章,通过在小鼠肺癌模型中进行了 CRISPR 筛选,发现结节性硬化症复合体亚基 1(Tsc1)和亚基...
immunecheckpointblockadeincancertherapy癌症治疗中的免疫检查点阻断剂 系统标签: blockadecancercheckpoint检查点immunetherapy ImmuneCheckpointBlockadeinCancerTherapyJamesP.Allison,Ph.D.LudwigCenterforCancerImmunotherapyHowardHughesMedicalInstituteMemorialSloan-KetteringCancerCenterNewYork,NYWhilethereareexcitingexamplesofsuccessf...
1Pulsed Electric Field (PEF) treatment of progressive non-small cell lung cancer concurrently treated with immune checkpoint blockade: Acasereport. 脉冲电场 ( PEF ) 治疗进展性非小细胞肺癌同时接受免疫检查点阻断治疗 : 一例病例报告。影响指数 :暂无 ...
Immune Checkpoint Blockade: Subjugation of the Masses 123 http://dx.doi.org/10.5772/67687 2.2. CTLA-4 blockade Successes of cytotoxic lymphocyte associated antigen-4 (CTLA-4) monoclonal antibody blockade have been reviewed extensively in Ref. [13]. Briefly, patients with advanced stage melanoma ...
Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2015;27(4):450-461. 5. Saha A, Aoyama K, Taylor PA, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 ... CG Kanakry,EJ Fuchs,L Luznik - 《Nature Reviews Clinical...
REVIEWS The blockade of immune checkpoints in cancer immunotherapy Drew M. Pardoll Abstract | Among the most promising approaches to activating therapeutic antitumour immunity is the blockade of immune checkpoints. Immune checkpoints refer to a plethora of inhibitory pathways hardwired into the ...
Immune checkpoint blockade: a common denominator approach to cancer therapy. The immune system recognizes and is poised to eliminate cancer but is held in check by inhibitory receptors and ligands. These immune checkpoint pathways, which normally maintain self-tolerance and limit collateral tissue ...
17 While multiple studies have shown tremendous success in treating cancers with antibodies that block inhibitory receptors on T-cells (immune checkpoint blockade, ICB) it is unclear why some individuals respond and others do not. The anti-tumour clinical response to PD-1 blockade in patients with...