Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha Oncostatin M and response to biologic therapies. Art...
6d). Notably, we detected a significant decrease in soluble IL-2Rα, a pro-inflammatory cytokine that has been shown to enhance the development of Th17 cells and to exacerbate autoimmunity in EAE mice38 (Fig. 6d). To determine whether Tiam1 and Rac1 expression is altered in the ...
There were no significant differences in the distribution of allelic and genotypic frequencies between patients and controls for theIL4Rpolymorphism' analysed. These results support the existence of a significant association betweenGSTP1rs1695 andIL13rs20541 SNPs, with susceptibility to asthma, in the...
The '3D object counter' function of FIJI (ImageJ2) was used to determine the number of Tiam1/Rac1 and Tiam1/RORg interactions per cells. Due to the more than 500-fold signal amplification properties of the PLA assay, each interaction of a single Tiam1 and Rac1 molecule (or Tiam1 ...
评论次数: 0 文档热度: 文档分类: 待分类 文档标签: NFnf意义IL17AB与PR不明原因PR自然流产的 系统标签: 流产表达abortion原因组织deteted 目录缩略词表………1中文摘要………3Abstract………・5前言………・7日U舌………一。7材料和方法…
免疫原:详见说明书货号:Hz-R1183 用途范围:科研使用规格:50ul/100ul/200ul 是否进口:否是否单克隆:详见说明书 保质期:12个月抗原来源:详见说明书 标记物:详见说明书产品用途:WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet teste...
The term “Fc receptor” or “FcR” refers to a receptor that binds to the Fc region of an antibody. Human FcRs of natural sequence are preferred, and preferably receptors that bind to IgG antibodies (gamma receptors), which include the FcγRI, FcγRII and FcγRIII isoforms, as well...
Mebius, D.R. Littman Requirement for RORγ in thymocyte survival and lymphoid organ development Science, 288 (2000), pp. 2369-2373 View in ScopusGoogle Scholar 25 E. Bettelli, T. Korn, M. Oukka, V.K. Kuchroo Induction and effector functions of TH17 cells Nature, 453 (2008), pp. ...
询价产品: Anti-IL17A antibody LM890237R *联系信息: 产品信息 联系方式 品牌 联迈生物/LMAI Bio 产品名称 Anti-IL17A antibody 用途类别 仅供科研实验使用 有效成分含量 详见说明 包装规格 50μl/100μl 产地 中国上海 厂家 上海联迈生物工程有限公司 货号 LM890237R Anti-IL17A antibody 产品描述 ...
In accordance, the mutant allele was unable to regulate IL4Rα signaling. Further, patient cells were unresponsive to IL4/IL13 while on monoclonal antibody therapy. Together, this study reports a novel SOCS1 mutation and suggests that IL4Rα blockade may serve as an unexpected, but fruitful ...