免疫原:详见说明书货号:Hz-R1183 用途范围:科研使用规格:50ul/100ul/200ul 是否进口:否是否单克隆:详见说明书 保质期:12个月抗原来源:详见说明书 标记物:详见说明书产品用途:WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet teste...
(3)流产组蜕膜细胞胞浆中IL.17A与胞核中NF.1cB呈正相关(间.50,P<0.05),与胞浆中NF.rd3呈负相关(r---0.50,P<0.05);流产组蜕膜细胞核内NF.KB与核内PR呈负相关(r=.0.51,P<0.05),核内NF.rd3和与胞浆内PR呈负相关(r-一0.51,P<0.05)。结论(1)早期自然流产患者母胎界面蜕膜组织IL-17A和NF.rBmRNA...
The secondary structure of IL17A was predicted using PsiPred (http://bioinf.cs.ucl.ac.uk/psipred/) [42,43] and DiAminoacid Neural Network Application (DiANNA) (http://clavius.bc.edu/~clotelab/DiANNA/) [44]. Both methods predict protein cysteines that create disulfide bonds, but while Psi...
the mutant allele was unable to regulate IL4Rα signaling. Further, patient cells were unresponsive to IL4/IL13 while on monoclonal antibody therapy. Together, this study reports a novel SOCS1 mutation and suggests that IL4Rα blockade may serve as an unexpected, but fruitful therapeutic ...
Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U. Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha Oncostatin M and response to biologic therapies. Art...
There were no significant differences in the distribution of allelic and genotypic frequencies between patients and controls for theIL4Rpolymorphism' analysed. These results support the existence of a significant association betweenGSTP1rs1695 andIL13rs20541 SNPs, with susceptibility to asthma, in the...
We thank Allison R. Pettit for critical review of the manuscript. This work was supported by the University of Queensland Early Career Researcher Grant and New Staff Research Start-Up Grant. We thank Iwakura for the Il17-/- mice. We thank Nick Matigian for assistance in the microarray study...
Blinatumomab (BT), a CD19/CD3 bispecific T-cell engager (BiTE) antibody recently approved for treatment of relapsed/refractory acute lymphoblastic leukemia (r/r ALL), has resulted in a 40-50% complete response (CR)/CR with incomplete cou... N Jeyakumar,I Aldoss,D Yang,... - 《Blood...
Glimcher, R.S. Blumberg The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease J Exp Med, 195 (2002), pp. 1129-1143 View in ScopusGoogle Scholar 5 F. Heller, I.J. Fuss, E.E. Nieuwenhuis, R.S. Blumberg, W. Strober Oxazolone ...
Mori, T., Takada, R., Watanabe, R., Okamoto, S. & Ikeda, Y. T-helper (Th)1/Th2 imbalance in patients with previously untreated B-cell diffuse large cell lymphoma.Cancer Immunol. Immunother.50, 566–568 (2001). ArticleCASGoogle Scholar ...