In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immuneresponsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphismsassociated with high levels of IL-1beta activity increase the risk for ...
IL-1样细胞因子的几个特征明确的成员在炎症的发展和调节中起关键作用。IL-1α (IL-1F1)、IL-1β (IL-2F18) 和 IL-1 (IL-4F1) 是众所周知的炎症细胞因子,在炎症反应的启动和驱动 Th17 和 Th1 炎症反应中具有活性。相反,IL-1受体拮抗剂(IL-1ra;IL-3F36)和IL-36受体拮抗剂(IL-1ra;IL-5F33)通过...
In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immuneresponsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphismsassociated with high levels of IL-1beta activity increase the risk for ...
Human Th1 cells preferentially induce interleukin (IL)-1β while Th2 cells induce IL-1 receptor antagonist production upon cell/cell contact with monocytes Human Th1 cells preferentially induce interleukin (IL)-1beta while Th2 cells induce IL-1 receptor antagonist production upon cell/ cell contact...
On one hand, IL-1 beta signaling activates immune cells and drives CD4+ T cell polarization to T helper type 1 (Th1) and Th17 cells, resulting in anti-tumor responses and mediation of acute inflammation (2,3). However, IL-1 beta also supports tumor growth and metastasis driven by ...
In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for...
Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. Interleukin 1β(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in...
(IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B...
9-Primary research area 10-Other research areas 11-Molecular weight The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathw...
IL-12是促炎细胞因子,其通过诱导IFN-Y产生和增强NK和T细胞的增殖和细胞毒性来促进Th1型应答。白细胞介素-23(IL-23)是二硫键连接的异二聚体,其由独特的p19亚基和IL-12的p40亚基组成。IL-23是一种促炎细胞因子,由某些病原体感染后由巨噬细胞和树突细胞产生。IL-23受体在Th17细胞上表达,IL-23负责Th17的...