We sought to determine the role of genetic variants in IL-1 beta, STAT3, STAT5B and TLR5 genes in conferring risk of RHD in two cohorts of RHD patients.Bhatt, MansiKumar, SurendraGarg, NaveenSiddiqui, Mohammad HarisMittal, Balraj
巨噬细胞/小胶质细胞衍生的IL-1β通过STAT3/NF-κB途径诱导胶质母细胞瘤生长| Kai, K., et al. 2022. Hum Cell. 35: 226-237. PMID: 34591282 IL-1β诱导的促炎性成纤维细胞微环境损害了肺祖细胞的功能。| Ciminieri, C., et al. 2023. Am J Respir Cell Mol Biol. 68: 444-455. PMID: 366088...
Eur J Pharmacol Potential cardioprotective effect of octreotide via NOXs mitigation, mitochondrial biogenesis and MAPK/Erk1/2/STAT3/NF-kβ pathway attenuation in isoproterenol … Pubmed:35500641 J Clin Med Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure...
STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice IL-23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 has proinflammatory activity, inducing...
Finally, detailed analysis of potentially involved signaling pathways points toward STAT3 and CEBPδ-mediated hepcidin induction independent of IL-6. In conclusion, our study demonstrates a strong NOX2-mediated hepcidin induction during macrophage differentiation. These differentiated macrophages are able to...
JAK2/STAT3IL-1 betaTrichophyton mentagrophytes (T. mentagrophytes) is the main cause of rabbit dermatophytosis. As the main pathogen-associated molecular pattern of T. mentagrophytes, the role of beta-glucan in the pathogenesis of rabbit dermatophytosis remains elusive. Keratinocytes (KC) are...
Stat3 plays a central role in NLRP3 inflammasome-mediated IL-1(beta) production and pyronecrosisEdwan, J HTran, T MAbuAsab, MGoldbachMansky, R TColbert, R A
ManganeseMicrogliaJAK2/STAT3CytokinesNeuroinflammationChronic manganese (Mn) exposure can lead to neuroiYinNanjingLifengNanjingDaiNanjingQijunNanjingJiangNanjingPeipeiNanjingZhuNanjingLinNanjingHaifengNanjingYaoNanjingNeurotoxicologyYin, L., Dai, Q., Jiang, P., Zhu, L., Dai, H., Yao, Z., et al. (...
Our studies demonstrate that canonical OSM signaling pathways (pERK, pSTAT3, and pAKT) all contribute to LOXL2 expression in MCF7 cells suggesting a possible mediator protein we identified as c-Myc. Furthermore, OSM-induced LOXL2 played a significant role in OSM promoted tumor growth and ...
WANG M,CRISOSTOMO P,LILLEMOE K,et al.Deficiency of TNFR1 protects myocardium through STAT3,SOCS3,and IL-6, but not p38 MAPK or IL-1 beta.Am Colle Surg. 2006Wang M,Markel T,Crisostomo P, et al.Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL...