Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structura...
Description: The eBioJM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Ralpha). IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL-2Rbeta and gamma chains, which are essential for signal ...
through the heterotrimeric complex of IL-15 R alpha, IL-2 R beta and IL-2 R gamma c, through the heterodimeric complex of IL-2 receptors beta and gamma common, through a novel 60-65 kDa IL-15 RX subunit found on mast cells. The binding of IL-15 to IL-15 R alpha has been ...
References Pappu, R.et al. (2012) Trends Immunol.33:343. Rubino, S.J.et al. (2012) Trends Immunol.33:112. Li, H.et al. (2000) Proc. Natl. Acad. Sci. USA97:773. Ramirez-Carrozzi, V.et al. (2011) Nat. Immunol.12:1159. ...
Interleukin 15 Receptor alpha (IL-15 R alpha) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction. IL-15 R alpha is expressed on a wide variety ...
il-15受体是一种i型细胞因子受体,由与il-2受体共有的beta(β)和gamma(γ)亚基以及以高亲和力结合il-15的alpha(α)亚基组成。全长人类il-15rα是一种1型跨膜蛋白,具有32个aa的信号肽、173个aa的细胞外结构域、21个aa的跨膜结构域、37个aa的细胞质尾和多个n-连接或o-连接的糖基化位点(anderson等人,j....
We use this strategy to design mimics of the central immune cytokine interleukin-2 (IL-2) that bind to the IL-2 receptor βγc heterodimer (IL-2Rβγc) but have no binding site for IL-2Rα (also called CD25) or IL-15Rα (also known as CD215). The designs are hyper-stable, ...
LTB4R 278 textmining:202; 202 IL5 CYCS 279 textmining:201; 201 IL5 B3GAT1 280 textmining:260; 260 IL5 BTK 281 textmining:170; 170 IL5 MMP14 282 textmining:157; 157 IL5 BMX 283 textmining:162; 162 IL5 PLG 284 textmining:215; 215 IL5 HRAS 285 textmining:462; 462 IL5 CD34...
Biron, C.A. Role of early cytokines, including alpha and beta interferons (IFN-α/β), in innate and adaptive immune responses to viral infections.Semin. Immunol.10, 383–390 (1998). ArticleCASGoogle Scholar Fellous, M. et al. Interferon-dependent induction of mRNA for the major histocompat...
在各种实施方案中,IL‑15结构域源自SEQ ID NO:1中列出的人类IL‑15前体序列的氨基酸序列: [0116] [0117] IL‑15受体是一种I型细胞因子受体,由与IL‑2受体共有的beta(β)和gamma(γ)亚 基以及以高亲和力结合IL‑15的alpha(α)亚基组成。全长人类IL‑15Rα是一种1型跨膜蛋白, 具有32个AA的...