Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity. Scand J Clin Lab Invest 2008;68:479-483.Bargagli E, Bianchi N, Margollicci M, Olivieri C, Luddi A, Coviello G, et al. Chitotrio‐ sidase and soluble IL-2 receptor: comparison of two markers...
The interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway is important in immunity, but is also involved in maintenance of self-tolerance. This paradox is further complicated by shedding of the IL-2Rα chain, revealing soluble (s)IL-2R. Binding of IL-2 to sIL-2R may either reduce ...
The signalling-competent IL-2 receptor (IL-2R) is expressed either as heterodimer or -trimer [4]. The dimeric IL-2R consists of the IL-2Rβ chain (CD122, shared with IL-15R) and the common γ chain (γc, CD132, shared with the receptors for IL-4/7/9/15/21) [4,5,6,7,8...
Sarcoidosis 0.000271442 1 0 BeFree Thyroid Diseases 0.000271442 1 0 BeFree Ocular Toxoplasmosis 0.000271442 1 0 BeFree Upper Respiratory Infections 0.000271442 1 0 BeFree Virus Diseases 0.000271442 1 0 BeFree Intestinal Volvulus 0.000271442 1 0 BeFree Wheezing 0.000271442 1 0 BeFree Lymphoma...
2013. The present invention relates to 7-aminocephalosporanic acid derivative for the use in the prevention and treatment of the diseases related to overproduction of interleukin 15 and interleukin 2, such as, rheumatoid arthritis, psoriasis, inflammatory bowel disease, sarcoidosis, T-cell leukemias...
29, found that the expression of IL-32 in sarcoidosis is positively correlated with the elevation of IDO and IL-10, possessing the ability to promote DC differentiation, foster the development of DCs or macrophages, leading to immune dysregulation and resulting in tumor immune escape. The ...
herpetic keratitis, conical keratitis, corneal epithelial dystrophy, keratoleukoma, ocular premphigus, Mooren's ulcer, scleritis, Graves' opthalmopathy, Vogt-Koyanagi-Harada syndrome, keratoconjunctivitis sicca (dry eye), phlyctenule, iridocyclitis, sarcoidosis, endocrine opthalmopathy, or the like...
By studying the binding interface of IL-7 with IL7Rα at the structural level, it has been demonstrated that most IL7RA SCID mutations locate outside of the receptor's binding epitope, and instead are concentrated mainly in the D1, D2, and WSXWS domains of the protein. Also,...
AIM2, absent in melanoma 2; ASC, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain; IL, interleukin; NLR, nucleotide-binding domain and leucine-rich repeat receptor; NLRC, NLR family CARD containing; NLRP, NLR family pyrin domain containing. The second ...
SARCOIDOSIS An idiopathic fibrotic disease of humans that has systemic effects. Its pathology is poorly understood, and there are limited treatment options. Rights and permissions Reprints and permissions About this article Cite this article Hunter, C. New IL-12-family members: IL-23 and IL-27, ...