More recent work validates the potent immunomodulatory molecules transforming growth factor-beta (TGF-尾) and interleukin-10 (IL-10) as key targets for AD pharmacotherapy. Methods: We have crossed transgenic mouse models of AD with mice bearing genetically engineered immune/inflammatory genes targeting...
8、.41-7.17) and IL - 10 (40.85 + 5.65) content increased significantly (P < 0.000);Compared with the control group after treatment, children with respiratory syncytial virus bronchiolitis MAO group TGF - beta and IL - 10 content in peripheral blood are obvious rising trend, but still signi...
TGF β(tratorm growth factor beta,TGF β)作为公认的促纤维化因子在MFB分化过程中起着重要作用,以往研究发现IL 10可在体内减弱TGF β的促纤维化作用[2]。本实验通过IL 10干预TGF β作用后的成纤维细胞,观察IL 10是否可影响TGF β刺激成纤维细胞转分化作用。 1 材料和方法材料 细胞:①人胚肺成纤维细胞株:...
结论在体外IL 10对TGF β刺激成纤维细胞的增殖、胶原产生及α SMA表达有抑制作用,且呈剂量依赖性关键字:白细胞介素 10;成纤维细胞;平滑肌肌动蛋白【Abstract】ObjectiveToexploretheeffectsofIL 10onTGF βinducedtradifferentiationoffibroblasts,multiplicatioandgenerationofcollagen.MethodsHumanembryolungfibroblastswerepided...
BMC Infectious Diseases (2024) 24:652 https://doi.org/10.1186/s12879-024-09494-8 BMC Infectious Diseases RESEARCH Open Access Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis Luana Leandro Gois1,2,3, ...
Interestingly, IL-10 deficient C57BL/6 mice receiving gene transfer remained tolerant to hF.IX and generated Treg that suppressed anti-hF.IX formation. Effects of TGF-β blockade were also minor in this strain. In contrast, in C3H/HeJ mice, a strain known to have stronger T-cell responses...
The cytokines IL-10 and TGF-beta regulate immunity and inflammation. IL-10 is known to suppress the extent of hepatic damage caused by parasite ova during natural infection with Schistosoma mansoni, but the role of TGF-beta is less clear. Cytokine blockade studies in mice revealed that anti-IL...
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Suppression by T regulatory (Tr) cells is essential for the induction of peripheral tolerance. Many types of CD4+ Tr cells have been described in a nu... MK Levings,R Bacchetta,U Schulz,...
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-beta. Genes Immun. 2014; 15: 511-520. Ref.: https://goo.gl/rRUDoJPalomares O, Martin-Fontecha M, Lauener R, Traidl-Hoffmann C, Cavkaytar... O Palomares,M Martín-Fontecha,R Lauener,... - 《Gen...
Methods The effect of single nucleotide polymorphisms (SNPs) and plasma transforming growth factor beta (TGF-β) and interleukin 10 (IL-10) levels on malaria pathology was investigated in a case–control study of 1862 individuals from two major ethnic groups in three regions with intense perennial...