while short-term blockage of IL-17 in the glands using gene therapy has improved some of the clinical signs in spontaneous SjSs-B6.NOD-Aec1Aec2mice13. Recent data have indicated
The HDAC6 siRNA experiment was performed in duplicate treatment with either HDAC6- or negative control siRNA (Qiagen), plus or minus IL-1. The TSA experiment was performed in singlicate with TSA or DMSO treatment, plus or minus IL1. Raw expression data were processed using R/Bioconductor ...
3A and B). The staining of M1 and M2 was confirmed with the fluorescence minus one (FMO) controls (Fig. S6). Collectively, these results demonstrated that pristane contributes to the polarization of macrophages toward the M2 phenotype systemically during atherosclerotic lesion formation. 3.4. ...
2C) as the second parameter corresponding to bone fragmentation, and volume of the soft tissue (as total volume minus total bone volume—Fig. 2D). Statistical analysis The p values were calculated with GraphPad Prism software, version 5.04 (Graphpad Software, Inc), using Gehan–Breslow–Wilcoxon...
ERp57 dysfunction has been shown to contribute to tumorigenesis in multiple malignances. However, the role of ERp57 in clear cell renal carcinoma (ccRCC) remains unclear. Cell proliferation ability was measured by MTT and colony forming assays. Western b
Notably, the pro-inflammatory cytokine IL-18 has recently emerged as a key player in neuroinflammatory and neurodegenerative processes, with wide behavioral and cognitive effects [17–19]. However, the time-dependent modifications of IL-18 expression within specific brain regions after a peripheral ...
CN is a very abundant, ubiquitously expressed, Ca2 + /calmodulin-dependent protein phosphatase which regulates a variety of cellular functions in multiple cell lineages including neurons, cardiac muscle, and lymphocytes [15,16,17]. Calcium dysregulation in neurons is a common feature in AD [...
The HDAC6 siRNA experiment was performed in duplicate treatment with either HDAC6- or negative control siRNA (Qiagen), plus or minus IL-1. The TSA experiment was performed in singlicate with TSA or DMSO treatment, plus or minus IL1. Raw expression data were processed using R/Bioconductor ...
IL-17 enhances tumor development in carcinogen-induced skin cancer. Cancer Res 70, 10112–10120, doi:10.1158/0008-5472.CAN-10-0775 (2010). 25. Wang, L. et al. IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 206, 1457–1464, doi:10.1084/jem....
Data are normalized to the media stimulation control (% IL-17A+ cells from the J8-DT stimulated group minus % IL-17A+ cells from the media stimulated group [to remove background]). Statistical analysis was performed using a nonparametric, unpaired Mann–Whitney U test (one-tailed) (*p <...