Defects in K + channel function have been linked to a number of heritable and acquired conditions leading to arrhythmia in affected patients. As we continue to characterize channel function biophysically, our mechanistic understanding of these conditions grows. Hopefully, this will continue to lead ...
结果1 题目关于长QT间期综合征的表述,不正确的是 A. 离子流的改变是基因分型的电生理基础 B. LQT1型为Iks外流缓慢 C. LQT2型为Ikr外流缓慢 D. LQT3型为INa持久缓慢内流 E. LQT1型首选美西律治疗 相关知识点: 试题来源: 解析 E 反馈 收藏 ...
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K Channelopathies (IKs and IKr)Channels, I
Bepridil differentially inhibits two delayed rectifier K1 currents, IKr and IKs, in guinea-pig ventricular myocytes. Br J Pharmacol 1999;128:1733-1738.Wang JC, Kiyose T, Kiriyama K, Arita M. Bepridil differentially inhibits two delayed rectifier K currents, Ikr and Iks, in guinea-pig ...
the time constants were 188 +/- 12 and 2510 +/- 185 ms (n = 25); increasing the pulse duration from 400 to 1000 ms (expected to increase IKs rather than IKr under these conditions) caused a significant increase in the amplitude of only the fast component of deactivation at -40 mV (...
Ion channels are pore-forming proteins that cross the lipid membrane of cells and selectively conduct ions across this hermetic wall. Ion channels are responsible for the generation of electrical signdoi:10.1007/978-1-84628-854-8_12Nicolas Lindegger PhDRobert S. Kass PhD...