参考文献: [1] Magistroni R, D’Agati DV, Appel GB et al New developments in the genetics, pathogenesis, and therapy of IgA nephropathy. Kidney Int. 2015; 88:74–989.
IgA 肾病(IgA Nephropathy,IgAN), 是我国最常见的肾小球疾病,是慢性肾炎中最常见的病理类型。 它是一个免疫病理诊断,即免疫荧光下 IgA 伴或不伴 C3 在肾小球系膜区沉积,光镜下的病理改变非常广泛,从轻微病变到新月体性肾炎(轻微病变型、毛细血管内增生型、FSGS 型、膜增生型、新月体型、增生硬化型、合并膜性...
虽然IgAVN和IgAN肾活检组织免疫荧光显示系膜IgA1沉积为主,可伴 IgG、IgM、C3和纤维蛋白原沉积;光镜显示系膜细胞增生,伴系膜基质增加、内皮细胞增生、节段肾小球硬化及细胞新月体形成;电镜显示系膜区电子致密物沉积,然而二者病理分型指标不同:前者采用儿童肾脏病...
其中IgAV肾损伤或IgAV肾炎(IgA vasculitis with nephritis,IgAVN)又称为紫癜性肾炎,是儿童最常见的继发性肾小球肾炎。IgA肾病(IgA nephropathy,IgAN)又称为Berger病,是全球最常见的原发性肾小球肾炎。关于IgAVN的报道始于1806年,而对IgAN的描述则始于1968年[1-2]。由于这两种疾病肾活检免疫病理特征均为以肾小球系...
6. Rauen T, Wied S, Fitzner C, et al. After ten years of follow-up, no differencebetween supportive care plus immunosuppression and supportive care alone in IgA nephropathy. Kidney Int. 2020;98(4):1044-1052. 7. He JW,Zhou XJ,Lv JC,Zhang H...
[10] Lv J, Liu L, Hao C, et al. Randomized phase 2 trial of telitacicept in patients with IgA nephropathy with persistent proteinuria[J]. Kidney International Reports, 2023, 8(3):499-506.
Gd-IgA1 synthesis in IgA nephropathy. JCI Insight. 2020;5(14). 3. Faria B, Canao P, Cai Q, et al. Arteriolar C4d in IgA Nephropathy: A Cohort Study. Am J Kidney Dis. 2020;76(5):669-678. 4. Yu GZ, Guo L, Dong JF, et al. Persistent Hematuria and Kidney DiseaseProgression ...
[21]HOU J H,LE W B,CHEN N,et al.Mycophenolate Mofetil Combined With Prednisone Versus Full-Dose Prednisone in IgA Nephropathy With Active Proliferative Lesions: A Randomized Controlled Trial [J]. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017,...
[6]Wheeler DC, Toto RD, Stefánsson BV, et al. A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy. Kidney Int. 2021;100(1):215-224. ...
2.The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int. 2009 Sep;76(5):534-45. 3.IgA肾病的临床特征和诊断.UTD.