This Review summarizes the latest findings in the pathogenesis of IgA nephropathy. Key Points IgA nephropathy is mediated by the deposition of IgA1 immune complexes Increased synthesis of aberrantly galactosylated IgA1 is the first step in disease pathogenesis and remains fundamental to the formation ...
Experimental IgA nephropathy induced by coxsack- ie B4 virus in mice. Lab Invest 1997; 17: 81-8.Yoshida K,Suzuki J,Suzuki S, et al.Experimental IgA nephropathy induced by coxsackie B4 virus in mice. American Journal of Nephrology . 1997...
Figure 4. Light microscopic findings of a renal tissue. Expansion of mesangial matrices with mesangial cell proliferation (periodic acid-Schiff staining) is shown. In Japan, the Japanese classification and the Oxford classification are used for the histological diagnosis of IgA nephropathy patients (Tab...
ARTICLE Received 12 Dec 2014 | Accepted 23 Apr 2015 | Published 1 Jun 2015 DOI: 10.1038/ncomms8270 OPEN Identification of new susceptibility loci for IgA nephropathy in Han Chinese Ming Li1,2,*, Jia-Nee Foo3,*, Jin-Quan Wang4,*, Hui-Qi Low3, Xue-Qing Tang1,2, Kai-Yee Toh3, ...
Following initial descriptions in the late 1960s1,2, it has slowly been recognized that IgA nephropathy is the commonest form of idiopathic glomerulonephritis in most Western countries and a major cause of end-stage renal failure. Perhaps the best thumbn
1. In plasma, the areas of PI 10-8.9 and PI 10-8.6 in IgA nephropathy were higher in the patients than in the controls. 2. In the 7.0% PEG precipitation, the area PI 8.1-6.1 was higher in the patients than in the controls. These findings suggest that a change in charge ...
Table 4 summarizes the original pedigree consisting of a father with biopsy-proven IgAN and a history of significant alcohol use (>160 g/day) but no overt liver disease, a mother with renal disease but biopsy findings more consistent with chronic ischemic changes and diabetic nephropathy, and ...
The prognosis of patients with IgA nephropathy (IgAN) is variable but overall not good. Almost all patients with IgAN are at risk of developing end-stage renal disease within their expected lifetime. The models presently available for prediction of the r
The findings are discussed in relation to human IgA and IgM nephropathies. Keywords: Mesangioproliferative nephropathy, IgM/IgA nephropathy, Nutritive antigens, Gliadin References 1. Brack M: IgM-mesangial nephropathy in callitrichids. Vet Pathol 1988;25:270–276. 2. Brack M: IgM-mesangial ...
(1993) Removal systems of immunoglobulin A and immunoglobulin A containing complexes in IgA nephropathy and cirrhosis patients: the role of asialoglycoprotein receptors. Lab Invest 69: 714–723 CAS PubMed Google Scholar Novak J et al. (2005) IgA1-containing immune complexes in IgA nephropathy ...