28. Jhee JH, Kang HY, Wu M, et al. Circulating CD89-IgA complex does not predict deterioration of kidney function in Korean patients with IgA nephropathy[J]. Clin Chem Lab Med, 2017, 56(1): 75-85. DOI:10.1515/cclm-2017- 0090. ...
This Review summarizes the latest findings in the pathogenesis of IgA nephropathy. Key Points IgA nephropathy is mediated by the deposition of IgA1 immune complexes Increased synthesis of aberrantly galactosylated IgA1 is the first step in disease pathogenesis and remains fundamental to the formation ...
IgA Nephropathy (IgAN) is the main cause of primary glomerulonephritis, globally. This disease is associated with a wide range of clinical presentations, variable prognosis and a spectrum of histological findings. More than fifty years after its first description, this heterogeneity continues to complic...
Figure 4. Light microscopic findings of a renal tissue. Expansion of mesangial matrices with mesangial cell proliferation (periodic acid-Schiff staining) is shown. In Japan, the Japanese classification and the Oxford classification are used for the histological diagnosis of IgA nephropathy patients (Tab...
Experimental IgA nephropathy induced by coxsack- ie B4 virus in mice. Lab Invest 1997; 17: 81-8.Yoshida K,Suzuki J,Suzuki S, et al.Experimental IgA nephropathy induced by coxsackie B4 virus in mice. American Journal of Nephrology . 1997...
Bringing medical advances from the lab to the clinic. 关键词:Sparsentan;IgA 肾病;Lancet IgA肾病是一种以IgA沉积为特征的慢性肾脏病,可导致肾功能逐渐衰竭。Sparsentan作为一种非免疫抑制性、单分子双重内皮素血管紧张素受体拮抗剂,在之前的临床试验中显示出显著降...
The prognosis of patients with IgA nephropathy (IgAN) is variable but overall not good. Almost all patients with IgAN are at risk of developing end-stage renal disease within their expected lifetime. The models presently available for prediction of the r
betweentheepisode,urineanalysis:persistentproteinuriaandhematuria(Pro＋BLD3＋)Lab：IgG:576↓,IgA:142,IgE:<28.3 C3:111,C4:27.8 BUN:13,Crea:0.6,albumin:3.9 DPL:1911mg/dayrenalbiopsy：IgAnephropathy Issue ❖WhatisIgAnephropathy?WhatisthereasonofIgAN?WhyhegetsIgAN？HowtotreatIgAN?Whataboutit's...
The findings are discussed in relation to human IgA and IgM nephropathies. Keywords: Mesangioproliferative nephropathy, IgM/IgA nephropathy, Nutritive antigens, Gliadin References 1. Brack M: IgM-mesangial nephropathy in callitrichids. Vet Pathol 1988;25:270–276. 2. Brack M: IgM-mesangial ...
IgA nephropathy, confirmed significant association following correction for multiple testing and shown there is an excess burden of common mtDNA variants in the case group with 75 SNPs present only in individuals with IgA nephropathy. Additionally, we have developed an efficient, cost-effective protocol...