IgA肾病(IgA nephropathy)是指肾小球系膜区以IgA 或IgA沉积为主的原发性肾小球病。 IgA肾病是肾小球源性血尿最常见的病因。1968年Berger首先描述本病,故又称Berger病。 流行病学 在亚太地区 ( 中国、日本、东南亚和澳大利亚等 ) 和西欧地区 ( 法国、意大利、西班牙等 ) 该病分别占原发性肾小球病的 20%-40%...
IgA肾病(IgA nephropathy, Berger's disease)是世界范围内常见病,是肾功能衰竭的主要原因之一。临床特征是,青年和儿童多见,复发性血尿,血尿发生时常伴上呼吸道感染,轻度蛋白尿,极少有肾病综合征,可有高血压,血清IgA水平升高。血清IgA水平升高可能与病毒感染及食物蛋白相关。由于血清IgA水平升高, IgA伴有C3大量沉积于...
iga肾病蛋白尿肾炎nephropathy强的松 •定义及病因•发病率及发病机制(了解)•临床表现及分型•诊断及鉴别诊断•治疗•护理定义•IgA肾病,又称Berger's病。是一种免疫病理学诊断名词。是以IgA为主的免疫球蛋白颗粒状弥漫沉积在肾小球系膜区及毛细血管袢的一系列临床症状及病理改变。IgA肾病病因分类•原发...
IgA nephropathy usually doesn't cause symptoms in the early stages. The disease can go unnoticed for decades and is sometimes first suspected when routine tests reveal protein and red blood cells in your urine that can't be seen without a microscope (microscopic hematuria). IgA肾病一般不会在早...
[4] ZHAI Y L, ZHU L, SHI S F, et al. Increased APRIL Expression Induces IgA1 Aberrant Glycosylation in IgA Nephropathy [J]. Medicine, 2016, 95(11): e3099. [5] Mathur, Mohit et al. “A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy.” The New England journal ...
9. Moldoveanu Z, Wyatt RJ, Lee JY, et al. Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int. 2007;71:1148-54. 10. Xu LX, Zhao MH. Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy. Kidney Int...
摘要 IgA肾病(IgA nephropathy,IgAN)是目前全球范围内最常见的原发性肾小球肾炎,20%～40%的患者在诊断后20年内进展为终末期肾病。IgAN的发病机制尚不明确,临床治疗主要以控制病情进展为主,缺乏特异性治疗方案。围绕半乳糖缺乏的IgA1(galactose-deficient IgA1,Gd-IgA1)开展的一系列研究提示IgAN发病涉及多个环节。该...
IgA nephropathy(IgAN)is a common primary glomerular disease.The abnormal increase of IgA molecules in serum can be regarded as the initiation stage of IgAN development, and the abnormal IgA antibody class switch process in B cells leads to ...
原发性IgA肾病诊治..原发性IgA肾病诊治循证指南(2016)解读原发性IgA肾病(IgA nephropathy)是世界范围内最常见的肾小球疾病,亦是导致终末期肾脏病的主要疾病之一。为规范我国儿科医生对该病的诊断和治疗,
[6] LV J, WONG M G, HLADUNEWICH M A, et al. Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial [J]. Jama, 2022, 327(19): 1888-98. ...