New Drugs Under Evaluation for Treatment of IgA Nephropathy. New drugs are being evaluated for the treatment of IgA nephropathy. These drugs target persistent proteinuria despite months of optimized supportive care. However, it is believed that some of these drugs could be beneficial in managing the...
IgA nephropathy is defined by the presence of IgA-dominant or co-dominant immune deposits within glomeruli. Biopsy specimens meeting these diagnostic criteria have a range of histological changes that are reflected in the variable clinical course of IgA nephropathy. The impact of histology on outcomes...
We calculated the sensitivity and specificity using nephrotic syndrome (NS) as the diagnostic criteria to identify MCD-IgAN. Then, excluding patients with a 24-h urinary total protein less than 0.5 g/day, incomplete clinical data, or less than the six-month follow-up,...
The purpose of this study was to investigate the correlation between podocyte related biomarker cofilin-1 and renal function, and explore the value of cofilin-1 in predicting the risk of renal adverse prognosis in IgA nephropathy (IgAN). Patients with pr
IgA nephropathy (IgAN), a mesangial proliferative glomeru- lonephritis (GN), is the most common GN in all parts of the world where renal biopsy is widely practiced. It is unique among glomerular diseases in being defined by immunohisto- chemical findings, i.e., mesangial deposition of IgA,...
To claim CE credit for this activity, please visit https://www.pharmacytimes.org/courses/preventing-progression-in-iga-nephropathy-a-managed-care-focus-on-emerging-therapies ABSTRACT Immunoglobulin A nephropathy (IgAN) is an autoimmune disease that is the most common cause of glomerulonephritis. ...
IgA nephropathy(IgAN)and Henoch Schonlein purpura nephritis(HSPN)are common primary and secondary glomerular diseases in children. Renal manifestations,pathological findings and treatments of both diseases are rather similar. Based upon personal clinical experiences,the author proposed some personal thoughts...
. So in this case, even though there's a very low density of deposit. Because there's those mild mesangial changes, and we have the clinical issue of microscopic hematuria, it fits together as, as, as you know, as qualifying or, or satisfying, you know criteria for IgA nephropathy....
Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis[J].Kidney Int, 2011,80(1):79-87. DOI: 10.1038/ki.2011.16 . 返回引文位置Google Scholar 百度学术 万方数据 [10] Johnson EF , Lehman JS , Wetter DA ,et al. Henoch-...
在研究153个美国白人IgA肾病(IgA nephropathy,IgAN)时首次发现血清中存在高水平的半乳糖缺乏的IgA1(galactosedeficient IgA1,Gd-IgA1)[1]。目前研究表明,Gd-IgA1在IgAN与紫癜性肾炎(Henoch-Schönlein purpura nephritis,HSPN)的起病中发挥着重要作用,其水平与IgAN与HSPN的病程、进展及预后有关[2,3]。血清中Gd...