(+) T cells reduced the differentiation of NSCs into astrocytes and instead promoted the differentiation of NSCs into oligodendrocytes.Conclusion In conclusion, CD8(+) T cells suppressed the proliferation of NSCs and promoted the differentiation of NSCs into astrocytes by the IFN-gamma-STAT1-GFAP/Al...
Using a STAT1-dependent reporter construct we show that IFN-gamma signaling can be enhanced as well as inhibited by simultaneous stimulation with either defined TLR agonists or whole-bacterial lysates. Short costimulation resulted in the amplification of IFN-gamma signaling and was attributable to the...
信号转导子和转录激活因子 1 (STAT1) 在 T 细胞中的信号促进 t 1 (TH1) 分化和白细胞介素-12 (IL-12R) 受体的表达。白细胞介素-12R 信号通过 STAT4 (p STAT4 表示 STAT4 活化磷酸化的形式) 进一步促进 TH1 扩张,导致了 γ-干扰素 (IFNgamma) 的表达。在的 TH1 环境适应性免疫反应控制肿瘤的生长。
Examines Stat1-independent regulation of gene expression in response to interferon-gamma (IFN-gamma). Identification of genes regulated by IFN-gamma in serum-starved Stat1-Null fibroblast; Usage of oligonucleotide array analysis; Regulation of immediate-early and chemokine gene expression.Ramana...
Liu, XiaoxiaZheng, YanfangLuo, MinglianLiu, WeifangZhao, YinZou, LiAJRI: American Journal of Reproductive ImmunologyEPHB4,a down stream target of IFN-gamma/STAT1 signal pathway,regulates endothelial activation possibly contributing to the development of preeclampsia. Liu X,Hu Y,Liu X,et al. ...
Wei B,Baker S,Wieckiewicz J, et al.IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells. American Journal of Transplantation .Wei B., Baker S., Wieckiewicz J., et al. IFN-gamma triggered STAT1-PKB/AKT signalling pathway ...
340 CHRONIC INFLAMMATION-ASSOCIATED IFN-GAMMA/STAT1-SIGNALING SUPPRESSES HEPATOCARCINOGENESIS BY SENSITIZING FOR P53-DEPENDENT APOPTOSISdoi:10.1016/S0168-8278(08)60342-6S. LuthS. ZanderJ. SchraderA. W. LohseJ. HerkelElsevier B.V.Journal of Hepatology...
Mutation of an IFN-stimulated regulatory element that binds IFN regulatory factor 1 appeared to enhance the response to IFN-gamma and LPS. These data show that STAT1 is necessary for the activation of Tap-1 gene expression in APCs and initiation of cellular immune responses. Furthermore, our ...
Cho HJ, Kim SK, Jin SM, Hwang EM, Kim YS, Huh K, Mook-Jung I (2007) IFN-gamma-induced BACE1 expression is mediated by activation of JAK2 and 政治ERK1/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in 大astrocytes. Glia 55:253-262....
IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. J Im- munol 166: 4481-4489, 2001.Suk K, Kim S, Kim YH, Kim KA, Chang I, Yagita H, Shong M, Lee MS: IFN-gamma/TNF-...