Background aim: Under the regulation of various oncogenic pathways, cancer cells undergo adaptive metabolic programming to maintain specific metabolic states that support their uncontrolled proliferation. As it has been difficult to directly and effectively inhibit oncogenic signaling cascades with ...
Most of the described AICAR effects require its metabolic conversion to the monophosphate form ZMP by adenosine kinase (2). As an intermediate of the purine de novo pathway, ZMP is naturally present in cells at low concentration (7). ZMP and its precursor SZMP are important regulatory ...
Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout
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We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Deciphering the role of plasma proteins in pancreatic cancer (PC) susceptibility can aid in identifying novel targets for diagnosis and treatment. We examined the relationship between genetically determined levels of plasma proteins and PC through a syst
The meta-analysis of seven selected studies unveiled a substantial number of genes exhibiting significant up-regulation (24,689) and down-regulation (18,074). These differentially expressed genes were further categorized into 2,497 significantly up-regulated and 2,573 significantly down-regulated Gene...
This approach was adopted as it was envisaged that it would help us to identify the common and specific features of SARS-CoV-2 that have enabled it to cause a pandemic as compared to the two previous strains that caused comparatively less spread. To this end, we searched the GEO database...
Under a Creative Commons license open access Referred to by Ironing out MAFLD: Therapeutic targeting of liver ferroptosis Cell Metabolism, Volume 36, Issue 10, 1 October 2024, Pages 2167-2169 Tuo Shao, Raymond T. ChungHighlights Summary The complex etiological factors associated with metabolic dysfun...
Here, we build a machine learning model to generate genome-wide gene essentiality predictions for C. albicans and expand the largest functional genomics resource in this pathogen (the GRACE collection) by 866 genes. Using this model and chemogenomic analyses, we define the function of three ...