The most potent, Mac128, had a sub-micromolar EC50 against the reporter virus, inhibited wild-type clade IV LASV, and reduced viral titers by 4 orders of magnitude. Mechanistic studies suggested that Mac128 inhibited viral replication at the level of the polymerase....
To identify the Leptspira species, the nucleotide sequence of the partial 16S rRNA was determined using Sanger sequencing with the PCR product (289 bp) on an automated sequencer (Applied Biosystems® 3500 Genetic Analyzer) at the National Institute of Biotechnology, Savar, Bangladesh (www.nib....