Aneuploid cells also exhibit elevated RAF/MEK/ERK pathway activity and are more sensitive to clinically-relevant drugs targeting this pathway, and in particular to CRAF inhibition. Importantly, CRAF and MEK inhibition sensitize aneuploid cells to DNA damage-inducing chemotherapies and to PARP inhibitors...
If a system can be described well by a general set of reaction rules, e.g., as is often the case in organic chemistry, the filters can be set for multiple steps in the exploration and the general reactivity is guided based on the available resources. However, if highly diverse chemical ...
available in HERON, the computing time for the step can be estimated. This enables one to refine the chosen selection step to be more inclusive or exclusive based on the targeted chemical space and available resources. One such example of an expansion preview alongside the protocol is shown in...
Benefit from the new resources in genetics, several works collected and analyzed the coordinates of specific HERV families, including HERV-K (HML-2) [19], HERV-K (HML-6) [20], HERV-K (HML-7) [21], HERV-K (HML-10) [22], and HERV-W [23]. Furthermore, a recent study provided...
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Thomas Moschakis: Writing – review & editing, Supervision, Resources, Funding acquisition, Conceptualization, Methodology, Project administration. Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to...
The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based drug discovery and toxicity assessment. Over t
The human digestive system is not directly accessible and translating the rapidly evolving preclinical knowledge associated with diagnostics and therapeutic interventions is not an easy task. Differences in the anatomy, biological processes and cell-type-specific expression patterns of the human digestive sy...
and other resources. The circuit could also be designed to detect serial activation of pathways (e.g., recombinase-driven readout depends on the prior expression of a distinct recombinase), which would allow for the screening of compounds that lead to differentiation. The advantage of memory coul...
Cell displaying the molecular pathways containing genes associated with human temperament as measured by the Temperament and Character Inventory. The genes influence the Ras-MEK-ERK (MAPK), PI3K-AKT-mTOR, and Protein Kinase A, B, C pathways that regulate associative conditioning (reproduced from Fig...