2010. Human haematopoietic stem cells express Oct4 pseudogenes and lack the ability to initiate Oct4 promoter- driven gene expression. J Negat Results Biomed 9: 2. doi: 10.1186/ 1477-5751-9-2.Redshaw Z, Strain AJ (2010) Human haematopoietic stem cells express Oct4 pseudogenes and lack the...
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the in vitro expansion of HSCs remains a challenge due to incomplete understanding of the signaling networks underlying HSC self-renewal. Here, we s...
Human hematopoietic cells express two forms of the cytokine receptor common γ—chain(γc)细胞分裂素受体人类造血细胞IL-2受体γ链... SHIYUFANG,MARYHILL,等 - 《细胞研究(英文版)》 被引量: 0发表: 1997年 Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor ?? Chain Is Essential ...
This population of cells has the phenotype of CD34/CD38 and more preferably CD34/CD38/HLA-DR. Cells within this population have been found to express CD13, CD33 and CD71. Hematopoietic stem cells can be used in a number of therapies, including autologous transplantation and in gene therapy....
Hematopoietic Cell Therapy Development View All Publications(2) Isolation and Culture of Non-adherent Cells for Cell Reprogramming.Andrianto et al.Journal of stem cells & regenerative medicine 2022 Intrinsic Immunity Shapes Viral Resistance of Stem Cells.Wu X et al.Cell 2018 JAN ...
Human embryonic stem cells (HESC) can potentially generate every body cell type, making them excellent candidates for cell- and tissue-replacement therapies. HESC are typically cultured with animal-derived 'serum replacements' on mouse feeder layers. Both of these are sources of the nonhuman sialic...
This population of cells has the phenotype of CD34/CD38 and more preferably CD34/CD38/HLA-DR. Cells within this population have been found to express CD13, CD33 and CD71. Hematopoietic stem cells can be used in a number of therapies, including autologous transplantation and in gene therapy....
(MPPs). With the aim to exploit niche cell properties for experimental and potential clinical applications, we analyzed the potential of primary ECs alone and in combination with MSCs to support theex vivoexpansion/maintenance of human hematopoietic stem and progenitor cells (HSPCs). Even though a...
The continuous and high turnover of cells in the blood system is strictly dependent on the existence of multipotent hematopoietic stem cells (HSCs) with a high self-renewal and regenerative capacity.1 Thus, HSCs are both required and sufficient for reconstitution of the entire hematopoietic system....
(given that our cells express twofold more GCase). Future experiments in an immunocompromised models of GD to allow engraftment and proliferation of human cells will establish the potential of these cells to correct the phenotype. Regardless of the outcome, future efforts aimed at increasing the ...